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Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.

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Drzewiecka A., Urbańska K., Matuszak Z., Pineiro M., Arnaut L. G., Habdas J., Ratuszna A., Stochel G.

2001

vol. 48

issue 1

277-282

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

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1 Acta Biochimica Polonica

1 2001

1 Arnaut L. G.

1 Drzewiecka A.

1 Habdas J.

1 Matuszak Z.

1 Pineiro M.

1 Ratuszna A.

1 Stochel G.

1 Urbańska K.

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Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.