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Synthesis, spectral studies and antimicrobial activity of newly chalcones and isoxazoles in diphenyl amine derivatives

100%
Bhoraniya N. C., Purohit D. M.
World News of Natural Sciences
|
2024
|
vol. 54
17-25
EN
A new series of compounds, namely 2-{[4'-(3''-aryl)-2''-propene-1''-one-phenyl]amino}benzoic acids (3a-3j) and 2-{[4'-(5''-aryl)isoxazol-3''-yl]phenyl amino} benzoic acids (4a-4j), were synthesized. The structures of these compounds were confirmed by 1H NMR, IR, Mass spectral analysis. The compounds (3a-3j) and (4a-4j) have been evaluated their antimicrobial activity.
2
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Synthesis, sprectral analysis and antimicrobial activity of 1,2,3-triazole and arylamide derivatives using 4-aminoantipyrine nucleus

81%
Pankhaniya P., Savaniya N. P., Purohit D. M.
World News of Natural Sciences
|
2024
|
vol. 54
159-169
EN
Pyrazole derivatives shows remarkable antibacterial activity, antifungal activity, anti-oxidant activity, anti-inflammatory activity, anticancer activity etc. In view of getting to synthesize 2-{4’-[1’,5’-Dimethyl-3’-oxo-2’-phenyl-pyrazol-4’-yl]aminomethyl-1H-1,2,3-triazol-1-yl}-N-arylethanamide derivatives (8a-8j) and 2-[(1’,5’-dimethyl-3’-oxo-2’-phenyl-pyrazol-4’-yl)amino]-N-arylethanamide derivatives (9a-9j). The structures of the compounds were analyzed by IR, 1H NMR, mass spectral data and TLC. The synthesized compounds were evaluated their antimicrobial activity with Gram-positive, Gram-negative bacteria and fungi.
3
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Synthesis, spectral studies and antimicrobial activity of thiosemicarboximide derivatives containing pyridine nucleus

81%
Patel H., Bhoraniya N., Pankhaniya P., Purohit D. M.
World News of Natural Sciences
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2024
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vol. 54
9-16
EN
The Thiosemicarboximide derivatives of (5a-5j) were synthesized by the condensation of Chalcone derivatives (4a-4j) with H2N-NH-CS-NH2 in the presence of glacial acetic acid. The structures of newly synthesized compounds were confirmed based on 1H-NMR, mass spectra, and IR data. All the newly synthesized compounds were screened for their antibacterial activity against Gram +ve Bacteria Bacillus subtilis, Staphylococcus aureus, and Gram –ve Bacteria Escherichia coli, Pseudomonas aeruginosa and Fungi Aspergillus niger.
4
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Synthesis, spectral study and antimicrobial activity of some new 2-n-butyl-4-chloro-5-formyl imidazole (BCFI) analogues

71%
Pankhaniya P., Savaniya N. P., Bhoraniya N. C., Patel H. K., Purohit D. M.
World News of Natural Sciences
|
2024
|
vol. 55
69-78
EN
New chalcone derivatives (7a-7j) and thiosemicarbazone derivatives (9a-9j) containing 2-n-Butyl-4-chloro-5-formyl imidazole nucleus have been synthesized and their chemical structure were evaluated using Infrared spectroscopy (IR), Ultra-violet spectroscopy (UV-Vis.), 1H-NMR spectroscopy and mass spectroscopy. All the synthesized compounds were evaluated for their anti-bacterial activities against Gram-positive bacteria Bacillus subtilis & Staphylococcus epidermidis and gram-negative bacterial strain Pseudomonas aeruginosa & Porteous vulgaris. The anti-fungal activity was evaluated against Aspergillus niger. The activity of the compounds were compared with known standards such as streptomycin and nystatin. Among the synthesized chalcone derivatives 7d, 7g & 7h are potentially active against bacterial strains & fungi. Among the thiosemicarbazone derivatives 9a, 9g, 9j & 9i are moderately active against bacterial strains. While 9d & 9j shows good anti-fungal activity.
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