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1

Co można odczytać z muszli mięczaka?

100%

Jakubik B., Lewandowski K.

Kosmos

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2016

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vol. 65

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issue 3

455-462

PL

Różnorodność muszli różnych gatunków mięczaków była, zwłaszcza dawniej, podstawą ich klasyfikacji systematycznej. Na muszlach ślimaków i małży żyjących kilka-kilkanaście lat często także odzwierciedla się historia ich życia osobniczego. U mięczaków wodnych takie czynniki środowiska jak: chemizm wody, żyzność, rodzaj dna, obecność lub brak przepływu, wpływają na wielkość muszli, grubość, wzrost. Widoczne na muszlach pierścienie zahamowania wzrostu, powstające regularnie w okresie zimy, mogą się tworzyć także z innych przyczyn, np. u małża racicznicy zmiennej (Dreissena polymorpha), latem podczas zakwitu bruzdnic w toni wodnej. Za deformacje muszli odpowiadać mogą pasożyty, kolonie racicznic przytwierdzone do innych mięczaków i utrudniające im wzrost czy mechaniczne uszkodzenia powodujące późniejszą odbudowę muszli. Literatura

EN

Diversity of shells of various mussel species was, particularly in the past, the basis for their taxonomic classification. Several-year old shells of snails and bivalves often reflect the history of their individual life. In aquatic mollusks, habitat conditions such as water chemistry, eutrophication, type of the bottom, water flow (if present) affect the size, thickness and growth of their shells. Annuli observed on shells are regularly formed in the wintertime but they may also appear for other than seasonal reasons. For example, in the zebra mussel (Dreissena polymorpha) annuli may appear in summer as a result of dinoflagellate blooming in water. Parasites, colonies of zebra mussel attached to other mollusks and impeding their growth or mechanical damages, are responsible for shell deformations, which may further affect shell reconstruction.

2

Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study

52%

Kowalik M., Lango R., Siondalski P., Chmara M., Brzeziński M., Lewandowski K., Jagielak D., Klapkowski A., Rogowski J.

Acta Biochimica Polonica

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2018

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vol. 65

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issue 2

241-250

EN

There is increasing evidence that genetic variability influences patients' early morbidity after cardiac surgery performed using cardiopulmonary bypass (CPB). The use of mortality as an outcome measure in cardiac surgical genetic association studies is rare. We publish the 30-day and 5-year survival analyses with focus on pre-, intra-, postoperative variables, biochemical parameters, and genetic variants in the INFLACOR (INFLAmmation in Cardiac OpeRations) cohort. In a prospectively recruited cohort of 518 adult Polish Caucasians, who underwent cardiac surgery in which CPB was used, the clinical data, biochemical parameters, IL-6, soluble ICAM-1, TNFα, soluble E-selectin, and 10 single nucleotide polymorphisms were evaluated for their association with 30-day and 5-year mortality. The 30-day mortality was associated with: pre-operative prothrombin international normalized ratio, intra-operative blood lactate, postoperative serum creatine phosphokinase, and acute kidney injury requiring renal replacement therapy (AKI-RRT) in logistic regression. Factors that determined the 5-year survival included: pre-operative NYHA class, history of peripheral artery disease and severe chronic obstructive pulmonary disease, intra-operative blood transfusion; and postoperative peripheral hypothermia, myocardial infarction, infection, and AKI-RRT in Cox regression. Serum levels of IL-6 and ICAM-1 measured three hours after the operation were associated with 30-day and 5-year mortality, respectively. The ICAM1 rs5498 was associated with 30-day and 5-year survival with borderline significance. Different risk factors determined the early (30-day) and late (5-year) survival after adult cardiac surgery in which cardiopulmonary bypass was used. Future genetic association studies in cardiac surgical patients should account for the identified chronic and perioperative risk factors.

3

Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study

52%

Kowalik M. M., Lango R., Łoś A., Chmara M., Brzeziński M., Lewandowski K., Klapkowski A., Rogowski J.

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EN

Background: Acute respiratory distress syndrome (ARDS) is a serious complication after cardiac surgery with a variety of clinical risk factors. It was hypothesized that genome variants predispose these patients to it. Material and methods: A cohort of 509 adult Caucasians undergoing on-pump cardiac surgery were observed for postoperative ARDS defined by the Berlin definition. Clinical variables and 10 single-nucleotide variants of genes involved in inflammatory pathways were analyzed for associations with four groups, defined by paO2/fiO2 (PF) ratio: 1) no ARDS (PF > 300 mmHg), 2) mild ARDS (200 < PF ≤ 300 mm Hg), 3) moderate ARDS (100 < PF ≤ 200 mm Hg), and 4) severe ARDS (PF ≤ 100 mmHg). Variables remaining in trends at p < 0.05 were considered significant. Results: The prevalence of ARDS was 7.9%. Only LBP1 rs2232582 remained in a genotypic trend with ARDS aggravation (p = 0.08). Clinical variables associated with ARDS aggravation: impaired left ventricular ejection fraction (p = 0.04), pulmonary hypertension (p = 0.01), intraoperative hypotension (p = 0.009), and postoperative day 1 white blood cell count (p = 0.015). More aggravated ARDS was associated with longer mechanical ventilation (p=0.01) and length of stay in ICU (p = 0.002). Conclusions: The borderline association with LBP1 rs2232582 and the identified risk factors suggest possible involvement of the LPS-LBP1 pathway in ARDS of the INFLACOR cohort.

4

Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study

52%

Kowalik M. M., Lango R., Łoś A., Chmara M., Brzeziński M., Lewandowski K., Klapkowski A., Rogowski J.

European Journal of Translational and Clinical Medicine

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2020

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vol. 3

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issue 1

24-33

EN

Background Acute respiratory distress syndrome (ARDS) is a serious complication after cardiac surgery with a variety of clinical risk factors. It was hypothesized that genome variants predispose these patients to it. Material and methods A cohort of 509 adult Caucasians undergoing on-pump cardiac surgery were observed for postoperative ARDS defined by the Berlin definition. Clinical variables and 10 single-nucleotide variants of genes involved in inflammatory pathways were analyzed for associations with four groups, defined by paO2/fiO2 (PF) ratio: 1) no ARDS (PF > 300 mmHg), 2) mild ARDS (200 < PF ≤ 300 mm Hg), 3) moderate ARDS (100 < PF ≤ 200 mm Hg), and 4) severe ARDS (PF ≤ 100 mmHg). Variables remaining in trends at p < 0.05 were considered significant. Results The prevalence of ARDS was 7.9%. Only LBP1 rs2232582 remained in a genotypic trend with ARDS aggravation (p = 0.08). Clinical variables associated with ARDS aggravation: impaired left ventricular ejection fraction (p = 0.04), pulmonary hypertension (p = 0.01), intraoperative hypotension (p = 0.009), and postoperative day 1 white blood cell count (p = 0.015). More aggravated ARDS was associated with longer mechanical ventilation (p=0.01) and length of stay in ICU (p = 0.002). Conclusions The borderline association with LBP1 rs2232582 and the identified risk factors suggest possible involvement of the LPS-LBP1 pathway in ARDS of the INFLACOR cohort.

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2 European Journal of Translational and Clinical Medicine

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4 Lewandowski K.

3 Brzeziński M.

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3 Klapkowski A.

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1 Jagielak D.

1 Jakubik B.

1 Kowalik M.

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Co można odczytać z muszli mięczaka?

Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study

Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study

Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study