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The effect of vasopressin analogue on memory process in rats with experimental amnesia

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Car H., Borawska M., Wisniewski K.

Acta Neurobiologiae Experimentalis

1995

vol. 55

issue 3

207-221

We investigated the effect of a single 2?g dose of vasopressin (AVP) analogue on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia.The models used were: electroconvulsive shock (ECS) and hypoxia.It severely impaired the memory processes.The AVP analogue facilitated retrieval of passive avoidance in all animals.

Bicuculline, AP-7 and behavioral activity in rats

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Car H., Kuziemka-Leska M., Wisniewski K.

Acta Neurobiologiae Experimentalis

1998

vol. 58

issue 2

159-164

The effects of bicuculline (0.25 mg/kg i.p.) and AP-7 (5 nmols icv) on the processes of retrieval, consolidation of conditioned reflexes, object recognition and locomotor activity were tested in rats. Neither AP-7, nor bicuculline nor AP-7 with bicuculline changed locomotor and exploratory activity in the open field test. Coadministration of AP-7 with bicuculline however, facilitated retrieval of passive avoidance in rats, but was without effect on consolidation in this test. Also neither AP-7 nor bicuculline when were given alone had an effect on influenced consolidation. We found no differences in effects of either AP-7 or bicuculline on object recognition regardless whether administered alone or in combination.

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2 Acta Neurobiologiae Experimentalis

1 1998

1 1995

2 Car H.

2 Wisniewski K.

1 Borawska M.

1 Kuziemka-Leska M.

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The effect of vasopressin analogue on memory process in rats with experimental amnesia

Bicuculline, AP-7 and behavioral activity in rats