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Związek polimorfizmów genów MCP-1 i CCR2 z występowaniem raka jelita grubego

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Walczak A., Przybyłowska-Sygut K., Sygut A., Cieślak A., Mik M., Dziki Ł., Dziki A., Majsterek I.
Polish Journal of Surgery
|
2017
|
vol. 89(5)
1-5
PL
Cel badania: Oceniono związek pomiędzy występowaniem wariantów dwóch polimorfizmów pojedynczego nukleotydu -2518 A/G MCP-1 oraz 190 G/A CCR2 z rakiem jelita grubego (RJG). Materiał i metody: Do badania włączono pacjentów z różnym stopniem zaawansowania RJG oraz osoby zdrowe. Genotypy oznaczono metodą reakcji łańcuchowej polimerazy – polimorfizmu długości fragmentów restrykcyjnych (RFLP-PCR). Wyniki: Zaobserwowano związek pomiędzy rakiem jelita grubego i genotypem GG polimorfizmu -2518 G/A MCP-1. Nie zaobserwowano natomiast istotnej statystycznie korelacji pomiędzy RJG a polimorfizmem 190 A/G CCR2. Wnioski: Wyniki tego badania potwierdzają hipotezę, że polimorfizm w promotorze genu MCP-1 może przyczyniać się do rozwoju raka jelita grubego.
2
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An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence

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Walczak A., Przybyłowska-Sygut K., Sygut A., Cieślak A., Mik M., Dziki Ł., Dziki A., Majsterek I.
Polish Journal of Surgery
|
2017
|
vol. 89(5)
1-5
EN
The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
3
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The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease

100%
Walczak A., Przybyłowska K., Sygut A., Dziki Ł., Chojnacki C., Chojnacki J., Dziki A., Majsterek I.
Polish Journal of Surgery
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2012
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vol. 84(5)
238-241
EN
Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development. Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn’s disease) as well as 210 healthy controls. Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn’s disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively). Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
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