This lecture consist of three parts, the first one gives a summary of mechanisms regulatting hemostasis and fibrynolysis, the second - discusses potential target molecules for therapeutic intervention, and the third one describes recent studies on selective inhibition of certain pathophysiological processes by molecules designed to prevent cardiovascular problems.Thus, a critical review of current trends in biotechnology of drugs which recently have been designed and tested to improve survival of patients with different cardiovascular diseases is provided.
Because both electrophysiological and behavioral methods have implicated the suprasylvian cortex of cat in audition, its afferents were studied using retrograde transport of horseradish peroxidase. The bulk-filling method was used to maximize the likelihood that virtually all afferents to the area would be labeled. Despite the vivid retrograde labeling of many thalamic cells with this procedure, no direct auditory projections to the suprasylvian cortex could be found in the thalamus (i.e. in medial geniculate body or in the dorsolateral part of the posterior nucleus). Furthermore, very few cells were labeled in the primary auditory cortex of the nearby ectosylvian gyrus. The source of afferents to the suprasylvian cortex originate mostly from the pulvinar-lateral posterior complex and to a lesser extent from ventral lateral and ventral anterior nuclei of the thalamus.
The cat's pons was isolated by two brainstem transections, at the junction of medulla and pons and at the junction of pons and midbrain.In the differented pons the EEG acticvity was virtually absent, whereas the spatial density of active units and the rate of their spontaneous spike activitry were at a high level.In the pons of control preparations with brainstem transected only at the ponto-midbrain junction the EEG activity was present, while the single-unit activity was such as in isolatesd pons.The electrical activity of the isolated pons was similar to that previously described in the cat's isolated midbrain.The discrepancy between EEG and a single-unit activity suggests that in the deafferented pons or midbrain many neurones are asynchronously autoactive.Also, these results show that a flat EEG record is not necessarily a sign of absence of the neural activity and neural death.
Ce_5CuPb_3 band structure has been calculated based on two ab initio methods: full potential-linearized augmented plane wave implemented in WIEN2k code and full-potential local-orbital minimum-basis in FPLO code. The calculations were performed with and without spin polarization. Starting from the generalized gradient approximation we additionally tested either an orbital polarization correction and the GGA+U approach with the Coulomb repulsion energies U varied from 0 to 6.7 eV within the Ce 4f electron shell. The calculations confirmed possible antiparallel alignment of the magnetic moments of the cerium atoms in the low temperature phase.
In this report we discuss the possibility of using antisense oligonucleotides specific to PAI-1 mRNA to reversibly decrease PAI-1 level in blood plasma and thus prolong a half-life time endogenous plasminogen activators in circulation.
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