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Role of recombinant human erythropoietin in the treatment of cancer-related anaemia

100%
Jankowski T., Kubiatowski T.
OncoReview
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2017
|
vol. 7
|
issue 2
98-103
EN
Anaemia is one of the most frequently diagnosed complications in cancer patients and also occurs during the course of cancer treatment. The condition can be observed in as many as 60–70% of patients who receive chemotherapy or radiotherapy. As a cancer symptom, it is found in 30% of cases and is particularly severe when accompanied by kidney failure. In patients undergoing cancer therapy, anaemia is treated with PRBC transfusions and/or recombinant human erythropoietin. The article discusses 3 case studies of patients with late-stage cancer (pleural mesothelioma, urothelial kidney carcinoma, and lung carcinoma), who suffered from moderate to severe anaemia during aggressive treatment with chemo- and radiotherapy. All 3 patients were treated with erythropoietin, which made it possible for them to stay on chemotherapy and/or undergo radiotherapy. Thanks to erythropoietin, they did not require PRBC transfusions and their general condition and quality of life improved. They tolerated the treatment well and no complications were observed.
2

Mechanical damage of animal cells in bioreactors

100%
Jankowski T., Grajek W.
Biotechnologia
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1993
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issue 3
166-183
EN
of animal cells due to forces generated by media agitation and aeration are reviewed. In anchorage-dependent cultures grown in a stirred bioreactor the cell damage is caused by small turbulent eddies of size of the microcarrier beads and by collision between and against the impeller and the stationary parts of bioreactor. In the freely suspended cells grown in stirred or s the cell damage is due mainly to air bibble breakup. The mechanical damages can be limited by an increase of kinematic viscosity of fluid and reduction to the local energy dissipation rate. Biological aspects of shear stress are also discussed.
3
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Off-label drug use in breast cancer therapy

100%
Jankowski T., Urbaniak M.
OncoReview
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2017
|
vol. 7
|
issue 2
83-87
EN
Breast cancer is one of the most common malignancies across the world, including Poland. Chemotherapy plays an important part in the treatment of the disease. Most of the available chemotherapy drugs and regimens have undergone randomized clinical studies and have been registered for that specific indication. However, a number of drugs are used in an off-label manner, i.e. outside the officially approved product specifications. The paper discusses the use of several off-label therapies in breast cancer in order to demonstrate that such treatment may be well-grounded and indeed turns out beneficial in many cases. It describes the use of liposomal doxorubicin in pre- and post-operative treatment, capecitabine for incomplete efficacy of preoperative treatment, and the administration of metronomic vinorelbine. Moreover, the paper is aimed at demonstrating the legal basis and the principles of marketing authorization of off-label drug use.
4
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Determination of phase diagrams and thermoseparation behaviour of aqueous two-phase systems composed of ethylene oxide–propylene oxide random copolymer and potassium phosphate

81%
Dembczyński R., Białas W., Jankowski T.
Chemical and Process Engineering
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2012
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vol. 33
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issue 3
411-429
EN
The application of aqueous two-phase systems (ATPS) is a cost-effective and simple method of protein separation (including enzymes) from complex systems. The first stage of designing the protein purification process in an ATPS involves the identification of the conditions for the formation of a given extraction system. For this purpose, the conditions for the formation of ATPSs in a thermoseparating EO50PO50 polymer/potassium phosphates system have been studied. Factors determining the ATPS formation comprised: separation temperature (4ºC or 20ºC), phosphate solution pH (6, 7.5 or 9) as well as the concentration of NaCl introduced into the systems (0.085 M, 0.475 M and 0.85 M). ATPS without NaCl were prepared as well. The conditions for the formation of the primary EO50PO50/potassium phosphate ATPS were determined with their phase diagrams. It was observed that with an increase of phosphate pH and NaCl concentration in the system, there was a decrease of the EO50PO50 and phosphate concentrations necessary to form a primary ATPS. After the primary two-phase separation, the top phase (rich in the EO50PO50 polymer) was partitioned from the bottom phase (rich in phosphates). Next, by means of polymer phase thermoseparation, a secondary two-phase system was formed. In the secondary EO50PO50/phosphate ATPS, the bottom phase was formed by the concentrated EO50PO50 polymer (30-80% concentration), while the top phase by a solution composed mainly of water, containing phosphate ions and remains of EO50PO50 polymer (3-7%).
5
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Biomonitoring of Inland and Inshore Waters with Use of Dreissena Polymorpha Mussels

81%
Matuszak P., Grodzicki G., Jankowski T., Matlakiewicz P.
|
2015
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vol. 52
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issue 3
49-53
EN
The pollution of water that is used for consumption and in agricultural holdings contributes to an increased mortality rate, inhibition of growth and physiological functions, changes in the DNA (genotoxicity), changes within tissues (cytotoxicity) and organs of individuals who are exposed to chemical components. One of the most dangerous toxin classes which have effect on animals and humans who come into contact with contaminated water is the class of cyanobacterial toxins released by dying cyanobacteria. They contribute to very serious health conditions and also to fatalities. Toxins of this type are relatively difficult to detect on account of their seasonal changeability in blooming. One of the most effective methods of detecting water contamination automatically and continuously is biomonitoring with the use of Dreissena polymorpha mussels.
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