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1

Recent views on Ca 2+ function and regulation of its concentration in the cell nuclei

100%
Bucki R., Gorski J.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
|
vol. 55
|
issue 1
157-175
EN
Ca 2+ is involved in the regulation of many events in the nucleus, such as gene expression, DNA replication, DNA repair, chromatin fragmentation in apoptosis, modulation of an intranuclear contractile system. In some cases, the function of Ca 2+ is mediated by calmodulin. However, the regulation of nucleoplasmic Ca 2+ concentration has not been explored throughly. The data discussed in this review show that the [Ca 2+]n may be regulated independently of that of cytosolic Ca 2+. IP3 and acid ADP-ribose are the major factors responsible for Ca 2+ release into the nucleus from perinuclear space.
2

Nuclear lipids

100%
Bucki R., Gorski J.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
|
vol. 51
|
issue 3
319-328
EN
The paper contains available data on the content, composition and metabolism of different lipid fractions in the nuclei. The results on physiological function of the nuclear lipids are also included. Nuclear phosphatidylinositols have been shown to play a role of messengers signalling from the cytoplasm to the nuclei. Most sphingomyeline is located in the nucleoplasm and it effect stability of DNA. A role of nuclear triacylglycerols remains unknown. Polyunsaturated long chain fatty acids control transcription of genes encoding lipogenic and glycolytic enzymes. Cholesterol present in the nuclear envelope plays probably only structural function, but that present in chromatin may be involved in regulation of cholesterol biosynthesis.
3

Carbohydrate matabolism in smooth muscles

100%
Swiatecka J., Gorski J.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
|
vol. 48
|
issue 1
77-89
4

Metabolic changes in denervated skeletal muscle

100%
Bockowski L., Gorski J.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
|
vol. 50
|
issue 2
191-204
EN
Section of the motor nerve of skeletal muscles produces severe atrophy and causes dramatic changes in biochemical properties of the muscles. Progressive decrease of oxidative and glycolytic activity, increased protein and purine degradation are prominent features of muscular atrophy. Denervation leads also to rapidly developing insulin resistance in skeletal muscles.
5

Various functions of human erythrocyte membrane lipids

81%
Bucki R., Sulpice J.-C., Giraud F., Gorski J.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
|
vol. 51
|
issue 6
637-650
EN
The major phospholipid classes of the human red blood cell membrane are: phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and sphingomyeli. These phospholipids are distributed asymmetrically across the two halves of the lipid bilayer. this asymmetry appears to be generated and maintained by an ATP-dependent translocation of aminophospholipids from outer to inner leaflet, and by the interaction of phospholipids with skeletal proteins. The phosphoinositides account for 3-4% of total erythrocyte membrane phospholipid. They play an important role in signal transduction and are involved in other various membrane functions.
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