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Schizofrenia u kobiet i mężczyzn

100%
Araszkiewicz A., Płocka-Lewandowska M.
Kosmos
|
2003
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vol. 52
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issue 1
97-103
EN
Summary The paper presents evidence suggesting that most male schizophrenic patients display poorer premorbid functioning during the early stages of the illness. In men, schizophernia onset is earlier than in women. Male patients more often display structural micro-abnormalities of the brain and organic deficits. Schizophernia in male population is rather more chronic and has poorer prognosis. Female patients are more often burdened with genetic factors. They express more often productive and affective symptomatology but they are more sensitive to neuroleptics. Moreover, the prognosis in their illness is more advantageous.
2
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Assessment of the frequency of the transforming growth factor beta-1 sequence polymorphisms in patients with alcohol dependence syndrome

61%
Augustyńska B., Araszkiewicz A., Woźniak M., Grzybowski T., Skonieczna K., Woźniak A., Żyła M.
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2015
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vol. 62
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issue 1
63-67
EN
Alcohol abuse is one of the most significant factors in the development of liver fibrosis. The pathomechanism of liver fibrosis is the same regardless of its etiology. Fibrosis is a sign of an imbalance between the synthesis of the extracellular matrix components and their degradation. Among the many cytokines that affect hepatic stellate cell activation it seems that transforming growth factor beta (TGF-β) is the most significant, either as the direct factor stimulating polymerase chain reaction (HSC) proliferation and transformation into myofibroblasts, or as the direct factor causing an increase in the activity of genes responsible for the synthesis of extracellular matrix components. The aim of the study was to reveal possible dependencies and differences between the presence of certain alleles of the TGF-β1 gene and its blood level in the study and control group. Blood samples were obtained from 39 patients, the control group consisted of 21 patients. The results obtained in the course of this study showed no statistically significant differences between the frequencies of particular polymorphisms. In the case of haplotype frequencies, insignificant differences were found for the algorithm Excoffier-Laval-Balding predicted haplotypes while one significant difference between the study and control groups was detected in case of the TC haplotype frequency predicted using the Expectation-Maximization algorithm. However, the difference in frequency of TC haplotype predicted by both algorithms was not significant. Genetic analysis of two single nucleotide polymorphisms (SNPs) in exon I of the TGF-β1 gene did not show significant differences between the occurrence of particular polymorphisms and haplotypes in the populations under study.
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