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St John's wort (Hypericum perforatum) counteracts deleterious effects of the chronic restraint stress on recall in rats

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Trofimiuk E., Walesiuk A., Braszko J. J.
Acta Neurobiologiae Experimentalis
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2006
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vol. 66
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issue 2
129-138
EN
This study aimed at verifying a hypothesis that St. John's wort (Hypericum perforatum) alleviates stress-induced memory impairments. Administration of Hypericum perforatum (350 mg kg-1 daily for 21 days) significantly enhanced recall of passive avoidance behavior (PAB), but had no effect on the acquisition of conditioned avoidance responses (CARs). Rats stressed chronically (2 h daily for 21 days) displayed diminished recall of the PAB and this effect was abolished by St John's wort. Chronic administration of the ?equivalent' to the stress dose of exogenous corticosterone (5 mg kg-1 daily for 21 days) also impaired recall of PAB, and this effect was also reversed by Hypericum perforatum. None of our treatments produced significant motor coordination impairments as tested in a ?chimney' test. It appears that H. perforatum prevents stress-induced deterioration of memory in rats.
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CGP 42112A abolishes facilitation of recognition caused by angiotensin II and angiotensin II(3-7) in rats

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Braszko J. J., Kulakowska A., Winnicka M. M., Karwowska-Polecka W.
Acta Neurobiologiae Experimentalis
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1997
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vol. 57
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issue 3
227-234
EN
The role of the angiotensin AT2 receptors in some behavioural effects of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole each, substantially improved object recognition memory and enhanced apomorphine (1 mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A per se ineffective in all tests, abolished activity of both peptides. None of the treatments significantly changed behaviour of rats in open field. The results point to the considerable involvement of the AT2 angiotensin receptors in the improvement of recognition memory caused by Ang II and Ang II(3-7).
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