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Design, synthesis and biological evaluation of a new bridged immunosuppressor.

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Szewczuk Z., Wilczyński A., Petry I., Siemion I. Z., Wieczorek Z.
|
2001
|
vol. 48
|
issue 4
1147-1150
EN
A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-γ-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.
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