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Evaluation of phytochemical, analgesic, acute toxicity and moisture content of Cumin cyminum

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Azubugwu C. M., Feridious N., Mostafa F., Ahmed B.
World News of Natural Sciences
|
2024
|
vol. 52
82-97
EN
The purpose of this study was to evaluate the analgesic, phytochemical screening, acute toxicity, and moisture content activity of the crude ethanolic seed extract of Cuminum cyminum and its n-hexane, chloroform, carbon tetrachloride and aqueous fraction. The ethanolic extract was used to the moisture content was found 43% evaluate analgesic, phytochemical screening, and moisture content activities. The analgesic activity was measured by acetic acid induced writhing test. The extract showed highly significant (p <0.001) analgesic activity with % inhibitions of writhing response at doses 250 mg/kg was 24.67% and 500 mg/kg was 36.95%. The moisture content was found to be 43%. The results of the study clearly indicate the present of analgesic, phytochemical screening and moisture content properties of the extract and its fractions. Phytochemical analysis revealed the presence of alkaloids, saponins, phenols, terpenoids and glycosides. Screening of analgesic property on mice by acetic acid induced method for crude extracts and its different fractions of Cuminum cyminum. At zero-hour test samples, control (1% Tween-80 solution in saline) and Diclofenac sodium were administered orally by means of a long needle with a ball shaped end. After 40 minutes acetic acid (1%) was administered intra- peritoneally to each of the animals of all the groups. The forty minutes interval between the oral administration of test materials and intra-peritoneal administration of acetic acid was given to assure proper absorption of the administered samples. Five minutes after the administration of acetic acid, number of squirms or writhing were counted for each mouse for ten minutes. Each mouse of all groups was observed individually for counting the number of writhing they made in 15 minutes commencing just 5 minutes after the Intra-peritoneal administration of acetic acid solution. Full writhing was not always accomplished by the animal, because sometimes the animals started to give writhing but they did not complete it. This incomplete writhing was considered as half-writhing. Accordingly, two half writhing were taken as one full writhing. In conclusion the ethanolic extract of C. cyminum seeds showed predominately showed significant analgesic activity.
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