Sea buckthorn (Hippophae rhamnoides L.) is a plant belonging to the Elaeagnaceae family. It is widely distributed throughout Asia, and Europe, especially in colder regions. Generally, sea buckthorn species vary in their phytochemical composition, depending on the climate, and soils in which they grow. Sea buckthorn has been used in traditional medicine for centuries, due to its rich chemical composition. The leaves, fruits, and seeds of this plant are a rich source of bioactive compounds, such as vitamins (A, E, K, C, B1, B2), phenolic compounds (e.g gallic acid, catechin, quercetin, kaempferol), fatty acids (e.g linoleic acid, α-linolenic acid, palmitoleic acid, vaccenic acid), amino acids (e.g glycine, isoleucine, cysteine, tyrosine, histidine, arginine), micro-, and macroelements. The presence of a large number of bioactive compounds results in a broad spectrum of biological activity. It has been shown that sea buckthorn has antioxidant, and anti–inflammatory properties, moreover it protects, and regulates cellular metabolism, has cardioprotective properties, and protective effect on skin cells. Research from recent years offers the hope that sea buckthorn preparations will be used in the treatment of, for example, skin burns, atopic dermatitis or abnormal cholesterol levels, but also as a support for the treatment of, for example, cardiovascular diseases.
Rats intoxicated with ethanol and acetaldehyde during 2 months showed increase of the thromboplastic activity in the kidney homogenate and decrease of this activity in the lung homogenate. Besides the intoxication with acetaldehyde increased activity of plasminogen in the homogenate of these organs. Antiplasmin activity decreased in the kidney and lung homogenates after one months and in the stomach homogenate after two months of intoxication with ethanol and acetaldehyde. The time of recalcination and the prothrombin time were slightly shorter in the plasma of rats intoxicated with ethanol and acetaldehyde and the fibrinogen level was increased. The time of the euglobulin fibrinolysis is slightly prolonged after the two months intoxication. The plasminogen level was simultaneously slightly increased. The antiplasmin activity was slightly decreased after one month of the intoxication with ethanol and acetaldehyde but in the second month of the intoxication the activity of this inhibitor was slightly -increased.