Ion channels selective for potassium or chloride ions are present in membranes of intracellular organelles such as mitochondria, sarcoplastic (endoplastic) reticulum, nucleus, synaptic vesicles, and chromaffin, and zymogen granules. They are probably important in cellular events such as compensation of electrical charges during intracellular transport of Ca 2+ and H+ and regulation of organelle volume changes. This review describes the basic properties, and current hypotheses concerning the functional role, and some aspects of experimental methodology of intracellular ion channels studies.
Ion channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They are probably important in cellular events such as regulation of organelle volume changes. Additionally, mitochondrial potassium channels are targets for potassium channel openers and antidiabetic sulfonylureas. This review describes properties, and current hypotheses concerning the functional role of mitochondrial ion channels.
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