Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 2

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Regulation of intracellular processes by fatty acids and end products of lipid peroxidation

100%
Przybyszewski W. M., Walichiewicz P.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 6
741-756
EN
Products of ingested fat metabolism and also products of lipid peroxidation influenced on genes expression being natural ligands for nuclear receptors functioning as a transcription factors. This situation creates possibilities of diet modification by type and amount of fat as an important element of cancer prevention and cancer therapy. Functioning and activity of PPARs indicating the way of controlling their activity by another ligands than that included in the diet. This is a base for pharmacologic synthesis of a new class of specific drugs as an agonists for nuclear receptors of precisely defined histologic type of cancer.
2

Fatty acids as a potential adjuvant in cancer therapy

100%
Przybyszewski W. M., Widel M.
|
|
issue 5
589-602
EN
This review presents pro- and anticancer effects of fatty acids in vitro and in vivo. The epidemiological and experimental data indicate that short-chain saturated and long-chain unsaturated omega-3 fatty acids exert protective effects against some cancers. In the contrary, omega-6 fatty acids are rather procancerous and can increase tumour proliferation. The possible mechanisms are still not fully understood and are very variable including: suppression of neoplastic transformation, direct cytotoxicity, apoptosis induction, antiangiogenicity etc. Experimental data indicate that fatty acid composition of cancer cells in cultures or in animals can be modified to make the cells more susceptible to lipid peroxidation, increasing the cell damage due to oxidant stress and make the cells more sensitive to chemotherapy. It is reasonable to suppose that fatty acids supplementation can make an enrichment of traditional tools for modern anticancer strategies.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.