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Zdrowotne oddziaływanie polifenoli zielonej herbaty (Camellia Sinensis L.)

100%
Nowak A., Klimowicz A.
Kosmos
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2013
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vol. 62
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issue 1
87-93
PL
Zielona herbata jest uzyskiwana z liści rośliny Camellia sinensis L. Jest jednym z najbardziej popularnych (obok wody) napojów spożywanych na świecie. Działanie zdrowotne zielonej herbaty, przypisywane polifenolom obecnym w suchej masie w około 20-40%, sprawia, że stanowi ona około 20% ogólnej ilości spożywanej herbaty (czarnej, czerwonej, żółtej itp.). Skład chemiczny tej odmiany jest taki sam w świeżych, jak i w suszonych liściach. Do podstawowych składników zaliczany galusan-3-epikatechiny, epigalokatechinę oraz galusan-3-epigalokatechiny. Ponadto zawiera kofeinę, teobrominę, teofilinę oraz inne ważne składniki jak aminokwasy, minerały, węglowodany, lipidy i witaminy. Po spożyciu zielonej herbaty zarówno w formie napoju jak i suchego wyciągu stwierdzono obecność polifenoli w krążeniu ogólnym. Regularna jej konsumpcja może wywierać działanie antyoksydacyjne, przeciwnowotworowe, przeciwbakteryjne, przeciwwirusowe oraz przeciwzapalne. Dodatkowo katechiny zawarte w zielonej herbacie mogą wpłynąć przynajmniej w wysokich dawkach na utrzymanie prawidłowej masy ciała u ludzi. Podsumowując, często spożywana zielona herbata może wywierać korzystny wpływ na ludzkie zdrowie.
EN
Green tea is a beverage made from the leaves of Camellia sinensis plant. It is the most popular, next to water, consumed liquid in the word. Due to the health promoting effect of green tea, attributed mainly to the high content of polyphenols (20-40 percent in dry mass), its consumption contributes about 20 percent to the world tea's consumption. The chemical composition of green tea and the fresh leaves is similar and consists of four kinds of basic polyphenols: epicatechin-3-gallate, epigallocatechin and epigallocatechin-3-gallate. In addition, there are present caffeine, theobromine and theophylline; also trace amounts of amino acids, minerals, carbohydrates, lipids and vitamins can be found. Tea polyphenols are bioavailable in the systemic circulation after administration of green tea as a beverage or as an oral product. The regular consumption of green tea as the beverage may lead to health benefits including antioxidant action, prevention of cancer, and antibacterial, antiviral as well as antiinflamatory effects. Moreover, green tea catechins, at least at high doses, may help to retain proper body weight. To sum up, the green tea seems to have a number of beneficial effects on the human health.
2
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Fotoalergeny i związki fototoksyczne pochodzenia roślinnego. Zagrożenia i korzyści terapeutyczne

81%
Muzykiewicz A., Nowak A., Klimowicz A., Florkowska K.
Kosmos
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2017
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vol. 66
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issue 2
207-216
PL
Reakcje fototoksyczne i fotoalergiczne są często występującymi schorzeniami skóry, wywoływanymi działaniem niektórych substancji stosowanych miejscowo i ogólnoustrojowo (fotosensybilizatorów) przy ekspozycji na promieniowanie UV. Fotosensybilizatorami miejscowymi są m.in. psoraleny, hiperycyna i pseudohiperycyna. Do roślin o potencjale fototoksycznym należą dziurawiec zwyczajny (zawierający hiperycynę i pseudohiperycynę) oraz rośliny z dużą zawartością psoralenów - przedstawiciele z rodziny selerowatych Apiaceae (np. barszcz Sosnowskiego, barszcz Mantegazziego, aminek większy) i rutowatych Rutaceae. Znajdujące się w okrywie owoców roślin cytrusowych olejki eteryczne również mogą wywoływać reakcje fototoksyczne i fotoalergiczne, powodowane głównie obecnością bergaptenu (5-metoksypsoralen). Oprócz potencjału fotoalergizującego i fototoksycznego, niektóre substancje pozyskiwane z tych roślin odgrywają ważną rolę w leczeniu chorób skóry przy użyciu fototerapii. W artykule przedstawiono również wyniki badań i omówiono wybrane przypadki kliniczne fotodermatoz.
EN
Phototoxic and photoallergic reactions following UV exposition are frequent skin disorders induced by certain topical and systemic substances, i.e. photosensitizers,. The group of topical photosensitizers includes among others psoralens, hypericin and pseudohypericin. To plants with a phototoxic potential belong St. John's wort (containing hypericin and pseudohypericin) and certain plants with a high psoralen content i.e. from members of Apiaceae family (Sosnowsky's hogweed - Heracleum Sosnowskyi, Heracleum Mantegazzianum, Ammi majus) and Rutaceae family. Essential oils from citrus fruit covers which contain bergapten (5-methoxypsoralen) can also induce phototoxic and photoallergic reactions. Apart from photoallergic and phototoxic activity certain substances isolated from the above mentioned plants are useful agents in the phototherapy of skin diseases. In the paper, there are also presented results of selected studies, as well as clinical case reports on photodermatosis.
3
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Comparison of the antioxidant potential of some herbal teas produced from ecological and traditional crops

81%
Wira D., Zielonka-Brzezicka J., Muzykiewicz-Szymańska A., Klimowicz A.
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
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2021
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vol. 17
97-103
EN
The growing public awareness of the dangers regarding chemicals used in traditional agriculture has led to consumers seeking valuable and contaminant-free products. Ecological agriculture has become synonymous with high health value and product safety. The aim of this study was to evaluate the antioxidant activity and the total polyphenolic content of infusions of herbal tea bags and loose teas from traditional crops, as well as infusions of loose teas from ecological crops. Raw material comprised dried flowers of Matricaria chamomilla and Tilia cordata, as well as dried leaves of Urtica dioica, Melissa officinalis and Mentha piperita. Herbal infusions were prepared using three brewing times: 5, 10 and 20 min. The analysis of antioxidant potential was performed using in vitro methods such as DPPH, ABTS and FRAP. The polyphenolic content was determined using the Folin-Ciocalteu method. The antioxidant activity of the studied tea infusion depended on the method by which the plants were cultivated and the brewing time. The ecological agriculture conditions seem not to stimulate the synthesis of antioxidants. However, the possibility to obtain other beneficial properties of the studied plants is an indication to carry out ecological cultivation.
4
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COMPARISON OF ARTIFICIAL HYDROPHILIC AND LIPOPHILIC MEMBRANES AND HUMAN SKIN TO EVALUATE NIACINAMIDE PENETRATION IN VITRO

52%
Nowak A., Church M. K., Duchnik W., Różewicka-Czabańska M., Bielecka-Grzela S., Prowans P., Pietriczko J., Czapla N., Bargiel P., Klimowicz A.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 2
271-279
EN
The evaluation of skin penetration of active substances from topical preparations is a pre-clinical requirement in the pharmaceutical industry. While in vitro preparations of human or animal skin are frequently used the development of artificial lipophilic and hydrophilic membranes with similar properties to human or animal skin need to be developed. This preliminary study compared the in vitro permeation of niacinamide (vitamin B3), which is used as a model drug, across artificial hydrophilic and lipophilic membranes with iv vitro penetration across human skin. The experiments were carried out in Franz diffusion cells. Artificial membranes were filter paper impregnated with either collodium (hydrophilic), stearic acid, cetyl alcohol or cetyl alcohol + cholesterol (lipophilic). Acidic and neutral hydrogel and emulsion (pH 5.4 and 7.4) containing 0.5% of niacinamide were applied to membranes for up to 4 hours. Niacinamide permeated hydrophilic better than lipophilic membranes. There were no significant differences between the cumulated amounts of niacinamide that penetrated artificial lipophilic membranes consisting of, stearic acid, cetyl alcohol and cholesterol as compared with human skin in vitro. Also, hydrogel and emulsion solvents gave similar results. In conclusion, these artificial membranes seem to be a promising alternative to human or animal skin.
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