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Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

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Ensoli F., Fiorelli V., De- C. M., Santini M. D., Novi A., Isgro A., Aiuti F.
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vol. 48
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issue 4
259-266
EN
Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
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