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1

Serological studies of cross-reactions between strains of Proteus mirabilis OXK (PrO 10/52) and Proteus mirabilis S1959

100%
Swierzko A., Cedzynski M., Ziolkowski A., Kaca W.
Postępy Higieny i Medycyny Doświadczalnej
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1996
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vol. 50
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issue 5
507-509
EN
Strong cross-reactions are described between Proteus mirabilis strains having the same structures of repeating units of their O-specific polysaccharides. These strains are used in routine diagnosis of ricketsiae.
2

Structure and serological characterization of an N-[(R)-1-carboxyethyl]-L- -lysine-containing the O-chain of the lipopolysaccharide of Proteus mirabilis O13

76%
Swierzko A. A., Cedzynski M., Ziolkowski A., Senchenkova S. N., Perepelov A. V., Knierel Y. A., Kaca W.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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vol. 49
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issue 2
163-170
EN
In this paper we present the structure and describe serological properties of the O-specific polysaccharide of Proteus mirabilis O13 lipopolysaccharide, which contains a unique component, an amide of D-galacturonic acid (D-GalA) with an unusual amino acid N-[(R)-1-carboxyethyl]-L-lysine (alaninolysine, AlaLys). Selective chemical degradations of either GalA or AlaLys resulted in the loss of the serological reactivity of the polysaccharide with anti-O serum against P. mirabilis O13. Neither synthetic stereoisomers of AlaLys nor the isolated amide of GalA with AlaLys inhibited the reaction of the O-antiserum with the homologous lipopolysaccharide. The O-antiserum did not cross-react with the lipopolysaccharide of Providencia alcalifaciens O23 containing an amide of D-glucuronic acid with AlaLys. These data showed that both uronic acid and amino acid components of the amide play an important role in manifesting the P. mirabilis O13-specificity, but the full specific epitope also includes also another OPS component(s). A cross-reactivity of anti-O13 serum with some other P. mirabilis strains was observed and attributed to a common heat-stable antigen(s) different from the lipopolysaccharide.
3

Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults

64%
Cedzynski M., Madalinski K., Gregorek H., Swierzko A. S., Nowicka E., Obtulowicz K., Dzierzanowska-Fangrat K., Wojda U., Rabczenko D., Kawakami M.
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issue 1
69-75
EN
The study was performed in 65 patients with HAE and 113 healthy persons. The parameters measured were C1-INH, C4, MBL concentration and MBL/MASP-2 complex activity, and serological markers of H. pylori, HBV, and HCV infection. Scores for the frequency and severity of HAE symptoms were determined. Results: HAE scores were significantly higher in patients whose C1-INH activity did not exceed 10% than in patients with activity of 10?52% (p=0.016). No significant differences were found in the median levels of MBL concentration and MBL/MASP-2 complex activity between patients and the control group. There was a slight association between contact with H. pylori in patients and HAE symptom score (p=0.052, not significant). Adult patients showed a 2.6-times higher frequency of anti-HBc than the general population. HBV DNA was negative in anti-HBc(+) patients. Conclusions: These results suggest that the MBL complement activation pathway itself does not contribute to the frequency of angioedema attacks. Infections with H. pylori and HBV may slightly influence the disease score (not significant).
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