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1

Function, properties and clinical significance of N-acetyl-beta-D- /HEX/

100%
Ostrowska L., Zwierz K., Koniusz Z., Gindzienski A.
Postępy Higieny i Medycyny Doświadczalnej
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1993
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vol. 47
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issue 1
67-80
EN
Function, and consequence of the of (HEX A> or , were described. The diagnostic value of the HEX determination in the and was reviewed.
2
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Role of N-acetyl-β-d-hexosaminidase in cholesteatoma tissue

100%
Olszewska E., Olszewski S., Borzym-Kluczyk M., Zwierz K.
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EN
Cholesteatoma is a destructive disease characterized by the progressive expansion of keratinizing squamous epithelium in the middle ear and mastoid, and chronic inflammatory reaction of the subepithelial connective tissue. N-Acetyl-β-d-hexosaminidase (HEX) catalyzes the release of terminal non-reducing N-acetyl-d-hexosamine residues acting on glucosides and galactosides in glycoproteins, GM2-gangliosides and glycosaminoglycans (GAGs). In this study the activities of HEX were measured in cholesteatoma tissue and in normal skin to demonstrate a possible role of HEX in bone resorption in the area adjacent to cholesteatoma. Cholesteatomas (n = 21) and normal adult retroauricular skin (controls, n = 21), were collected from patients during surgery due to chronic otitis media. In 20 of 21 specimens a significantly higher activity of HEX was observed in cholesteatoma tissue compared with that in normal skin. Mean release of HEX from the activated cells was 68.55 ± 30.77 nkat/g wet tissue in cholesteatoma and 31.79 ± 10.02 nkat/g wet tissue in skin specimens. It may explain the process of bone resorption in the area adjacent to cholesteatoma, i.e. ossicles or temporal bone. This study suggests that drugs inhibiting HEX activity, such as iminocyclitols, may be useful in cholesteatoma treatment.
3
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Structure and biosynthesis of human salivary mucins.

100%
Zalewska A., Zwierz K., Żółkowski K., Gindzieński A.
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2000
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vol. 47
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issue 4
1067-1079
EN
Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain havily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.
4
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The carbohydrate moiety of human glycophorin in CDG syndrome

87%
Krotkiewska B., Zwierz K., Krotkiewski H.
Acta Biochimica Polonica
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1999
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vol. 46
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issue 2
371-376
5
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Determination of lysosomal exoglycosidases in human saliva

76%
Chojnowska S., Zalewska A., Knaś M., Waszkiewicz N., Waszkiel D., Kossakowska A., Zwierz K.
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2014
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vol. 61
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issue 1
85-90
EN
Background: Currently we observe a growing interest in human saliva as a non-invasive material for diagnosis and monitoring of general and oral diseases. Methods: The aim of our study was adaptation of the Marciniak et al. (Marciniak J, Zalewska A, Popko J, Zwierz K, 2006, Clin Chem Lab Med 44: 933-937) method for determination of HEX and GLU activity in synovial fluid, and for determination of: HEX and GLU, as well as MAN, GAL, and FUC activity in human saliva. Results: Under optimal conditions, 10 μl of saliva for HEX, and 30 μl for GLU, MAN, GAL and FUC, were sufficient for determination of human salivary exoglycosidases activity with variation coefficient ranging from 0.89 for GLU to 0.99 for GAL. Conclusion: The adapted method for exoglycosidases activity determination in human saliva is sufficiently sensitive and precise to use in clinical diagnosis.
6
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Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures.

76%
Zalewska A., ska M. M. B., Marciniak J., Karaszewska K., Zwierz K., Moniuszko-Jakoniuk J.
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vol. 51
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issue 3
831-837
EN
Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of β-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, β-N-acetylhexosaminidase showed the highest activity. The activities of α;-mannosidase and β-galactosidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.
7
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Synthetic analogues of netropsin and distamycin - synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics

76%
Bartulewicz D., Bielawski K., Markowska A., Zwierz K., Pućkowska A., Różański A.
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8
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Influence of ethanol on the activity of glycosidases in rats exposed to cadmium (Cd^2+)

76%
Arciuch L. P., Omasta A., Rostkowska K., Gałażyn-Sidorczuk M., Moniuszko-Jakoniuk J., Zwierz K.
Acta Biochimica Polonica
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1995
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vol. 42
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issue 3
297-299
9
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Isoenzymes of N-acetyl-β-hexosaminidase in complicated pregnancy

76%
Arciuch L. P., Bielecki D., Borzym M., Południewski G., Arciszewki K., Różański A., Zwierz K.
Acta Biochimica Polonica
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1999
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vol. 46
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issue 4
977-983
EN
The activity of N-acetyl-β-hexosaminidase was found to be significantly higher in the placentas collected after delivery from women in puerperium with symptoms of prolonged pregnancy or complicated by EPH gestosis, than in placentas from normal pregnancy. Isoelectrofocusing of placenta homogenates showed the presence of isoenzymes A, P and B of N-acetyl-β-hexosaminidase. Different isoenzyme A patterns in homogenates were observed in placentas obtained from normal and prolonged pregnancies and in those complicated by EPH gestosis.
10
Content available remote

Isoenzymes of N- acetyl-β-hexosaminidase

63%
Zwierz K., Zalewska A., Zoch-Zwierz W.
Acta Biochimica Polonica
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1999
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vol. 46
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issue 3
739-751
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