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Diversity oriented, efficient and sustainable synthetic protocol for the synthesis of structurally diverse drug-like complex heterocycles, incorporating privileged heterocyclic systems

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Khandelwal S., Rajawat A., Tailor Y. K., Jain H. K., Kumar M.
Diversity Oriented Synthesis
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2012
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vol. 1
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issue 1
EN
A diversity oriented, efficient and sustainable synthetic protocol has been presented for the synthesis of structurally diverse drug-like small heterocycles with structural complexity. The present synthetic strategy involves a three-component domino reaction of 2-aminobenzothiazoles, thiophene-2-carbaldehyde and carbonyl compounds in the presence of a catalytic amount of sulfamic acid as a recyclable ecofriendly acid catalyst.
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