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Reconstitution of brain mitochondria inner membrane into planar lipid bilayer

100%

Kulawiak B., Bednarczyk P.

Acta Neurobiologiae Experimentalis

2005

vol. 65

issue 3

271-276

Ion channels are present in the inner mitochondrial membrane. They play an important role in cellular processes. Potassium and chloride channels are involved in regulation of mitochondrial volume, membrane potential and acidification. The mitochondrial potassium channels have been suggested as triggers and end effectors in cytoprotection. In our study we measured single channel activities after reconstitution of submitochondrial particles from rat brain mitochondria into planar lipid membranes. After incorporation, two different potassium selective currents were recorded with single channel conductance from 260 to 320 pS and from 70 to 90 pS in gradient (cis/trans) 50/450 and 50/150 mM KC1 solutions, respectively. We also observed activity of the chloride ion channel. The measured single channel conductance was from 80 to 90 pS in gradient {cis/trans) 50/450 mM KC1 solution. Our results suggest that various ion channels are present in the inner mitochondrial membrane of brain mitochondria.

The role and the function of voltage-gated chloride channels of the ClC family and its defects leading to genetic diseases

61%

Dolowy K., Bednarczyk P., Hordejuk R., Dworakowska B., Nurowska E., Jarzabek W.

Postępy Higieny i Medycyny Doświadczalnej

2002

vol. 56

issue 3

307-313

There are 9 channels of the ClC family in mammals and few others in fishes, plants, yeast and bacteria. The ClC channels are present in different tissues and play a role in transmembrane potential stabilization, transepithelial transport, cell volume regulation, acidification of intracellular organelles. The genetic defects of ClC-1 chloride channel lead to myotonias, the defect inClC-5 channel to the formation of stones in kidney, while the defect in ClC-Kb channel leads to the Bartter?s syndrome

Innovation technology for the production of massive slag ladles at the Krakodlew S.A. Foundry. Presentation of design works on research and development

51%

Paszkiewicz M., Guzik E., Kopyciński D., Kalandyk B., Burbelko A., Gurgul D., Sobula S., Ziółko A., Piotrowski K., Bednarczyk P., Paszkiewicz M., Guzik E., Kopyciński D., Kalandyk B., Burbelko A., Gurgul D., Sobula S., Ziółko A., Piotrowski K., Bednarczyk P.

Archives of Foundry Engineering

2020

vol. 20

issue 4

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1 Acta Neurobiologiae Experimentalis

1 Archives of Foundry Engineering

1 Postępy Higieny i Medycyny Doświadczalnej

1 2020

1 2005

1 2002

3 Bednarczyk P.

1 Burbelko A.

1 Dolowy K.

1 Dworakowska B.

1 Gurgul D.

1 Guzik E.

1 Hordejuk R.

1 Jarzabek W.

1 Kalandyk B.

1 Kopyciński D.

1 Kulawiak B.

1 Nurowska E.

1 Paszkiewicz M.

1 Piotrowski K.

1 Sobula S.

1 Ziółko A.

Search results

Reconstitution of brain mitochondria inner membrane into planar lipid bilayer

The role and the function of voltage-gated chloride channels of the ClC family and its defects leading to genetic diseases

Innovation technology for the production of massive slag ladles at the Krakodlew S.A. Foundry. Presentation of design works on research and development