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1

RNAi in therapy

100%
Kubiak K., Nawrot B.
Biotechnologia
|
2009
|
issue 1
132-151
EN
The discovery of RNA interference caused a revival of the concept of short nucleic acids application as molecular tools for therapeutic control of gene expression. After almost a decade of intensive research by leading pharmaceutical companies, there is only a limited number of clinical trials of synthetic siRNAs. In this review, we shall summarize the present status of knowledge of RNAi mechanism of action and discuss the potential of the use of siRNA in theraphy. We shall also provide data on recent achievements in current clinical trials based on RNAi techniques.
2
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Numerical Simulation of Directional Solidification Process of Single Crystal Ni- Based Superalloy Casting

81%
Sieniawski J., Szeliga D., Kubiak K.
Archives of Foundry Engineering
|
2017
|
vol. 17
|
issue 2
3
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Primary Creep Behaviour of Two-Phase Titanium Alloy with Various Microstructure

81%
Ziaja W., Sieniawski J., Kubiak K., Motyka M.
Archives of Metallurgy and Materials
|
2016
|
issue 2
4

Nitryle hydrytase ? Ligot activated industrial enzyme

81%
Peplowski L., Kubiak K., Nowak W.
|
2007
|
issue 1
63-76
EN
Since 1985, nitrile hydratases, metallo-enzymes present in bacteria from genus Rhodococcous, have been used for industrial production of acrylamide and related chemicals. The unique active site of both Fe- and Co-nitrile hydratases contains oxidized cysteines. Despite many efforts, details of the catalytic mechanism of activity and high selectivity remain unknown. Molecular structures, possible routes of hydration and prospects for applications of these photoactive enzymes in nanotechnology are discussed in this review.
5
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Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

81%
Niedźwiedź A., Kubiak K., Jaworski Z.
Polish Journal of Veterinary Sciences
|
2014
|
issue 4
6
Content available remote

Mould Walls Inclination and Dendritic Morphology of CMSX-4 Blades Airfoils

81%
Krawczyk J., Bogdanowicz W., Sieniawski J., Kubiak K.
|
EN
The airfoils of single-crystalline turbine blades were studied. The blades made of industrial CMSX-4 superalloy were obtained by the Bridgman technique. Five different withdrawal rates (1-5 mm/min) were used. Series of as-cast samples were prepared by cutting the airfoils at different distances from the blade root. The metallographic sections, prepared for each cutting planes, were subjected to scanning electron microscopy observations and Laue diffraction studies. Macrostructure images of whole area of airfoil cross-sections were obtained by stitching several obtained SEM images. Morphology of dendrites in different area of cross-sections were analysed. The crystal orientation of each sample were determined by analysis of Laue pattern. It was found that the morphology of dendrites changes in the area, where the dendrite growth is limited by inclined mould walls.
7
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Characterization of Casting Defects in the Single Crystal Turbine Blade Airfoil

81%
Albrecht R., Bogdanowicz W., Sieniawski J., Kubiak K.
Acta Physica Polonica A
|
2016
|
vol. 130
|
issue 4
1091-1093
EN
In the paper turbine blades made from single crystal CMSX-4 superalloy were investigated by X-ray diffraction methods (topography, Ω-scan mapping) complemented by scanning electron microscopy observations. By the X-ray diffraction topography method several misorientation defects were visualized as well as dendrites arrangement. It was discussed that tip of the airfoil and thin walled area of the turbine blades located near the trailing edge can accumulate more growth defects than other airfoil part, due to the complex shape of the mould.
8
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Methods for designing and simulating optical systems for luminaires

72%
Żagan W., Zalewski S., Słomiński S., Kubiak K., Żagan W., Zalewski S., Słomiński S., Kubiak K.
|
2020
|
issue 4
9
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Transthoracic lung and pleura ultrasonography as a diagnostic tool of pulmonary edema in dogs and cats

71%
Szymczak J., Kiełbowicz Z., Kinda W., Zaleska-Dorobisz U., Kubiak K.
Polish Journal of Veterinary Sciences
|
2018
|
vol. 21
|
issue 3
10
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Application of shear wave elastography in the diagnosis of mammary gland neoplasm in dogs

71%
Kubiak K., Glińska-Suchocka K., Jankowski M., Spużak J., Nicpon J.
Polish Journal of Veterinary Sciences
|
2013
|
issue 3
11
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Oesophageal foreign bodies in dogs

71%
Kubiak K., Jankowski M., Spużak J., Glińska-Suchocka K., Nicpoń J.
Polish Journal of Veterinary Sciences
|
2013
|
issue 3
12
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Sonoelastography in differentiation of benign and malignant testicular lesion in dogs

71%
Kubiak K., Glińska-Suchocka K., Jankowski M., Spużak J., Dzimira S.
Polish Journal of Veterinary Sciences
|
2014
|
issue 3
13
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Suitability of using serum hialuronic acid concentrations in the diagnosis of canine liver fibrosis

71%
Kubiak K., Glińska-Suchocka K., Orłowska A., Spużak J., Jankowski M.
Polish Journal of Veterinary Sciences
|
2015
|
issue 4
14
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Detection of Helicobacter spp. in the saliva of dogs with gastritis

71%
Jankowski M., Kubiak K., Spużak J., Glińska-Suchocka K., Biernat M.
Polish Journal of Veterinary Sciences
|
2016
|
issue 1
15
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Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis

71%
Glińska-Suchocka K., Kubiak K., Orłowska A., Jankowski M., Spużak J.
Polish Journal of Veterinary Sciences
|
2016
|
issue 2
16
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Accuracy of real-time shear wave elastography in the assessment of normal liver tissue in the guinea pig (cavia porcellus)

71%
Kubiak K., Glińska-Suchocka K., Spużak J., Jankowski M., Borusewicz P.
Polish Journal of Veterinary Sciences
|
2017
|
issue 1
17
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7S Fragment of Type IV Collagen as a Serum Marker of Canine Liver Fibrosis

71%
Kubiak K., Glińska-Suchocka K., Orłowska A., Spużak J., Jankowski M.
Polish Journal of Veterinary Sciences
|
2016
|
issue 3
18
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Detection of gastric Helicobacter spp. in stool samples of dogs with gastritis

71%
Jankowski M., Kubiak K., Spużak J., Glińska-Suchocka K., Biernat M.
Polish Journal of Veterinary Sciences
|
2016
|
issue 2
19
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An evaluation of the usefulness of invasive and non-invasive methods used to diagnose Helicobacter spp. infections in dogs

71%
Kubiak K., Jankowski M., Spużak J., Glińska-Suchocka K., Biernat M.
Polish Journal of Veterinary Sciences
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2017
|
issue 3
20
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Fine needle biopsy of abdominal organs in dogs – indications, contraindications and performance technique

62%
Kubiak K., Glińska-Suchocka K., Jankowski M., Spużak J., Dzimira S., Nicpoń J.
Polish Journal of Veterinary Sciences
|
2013
|
issue 4
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