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Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

100%

Alexandru M.-G., Velickovic T., Jitaru I., Grguric-Sipka S., Draghici C.

Open Chemistry

2010

vol. 8

issue 3

639-645

This paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control. [...]

Structural factors influencing the reaction rates of 4-aryloxy-7-nitrobenzofurazans with amino acids

73%

Bem M., Vasilescu M., Caproiu M., Draghici C., Beteringhe A., Constantinescu T., Banciu M., Balaban A.

Open Chemistry

2004

vol. 2

issue 4

672-685

An interesting observation was made when studying the SNAr reaction between several 4-aryloxy-7-nitrobenzofurazans (2) and several amino acids leading to the apparition of detectable fluorescence from the substitution products3. Acidic amino acids reacted very slowly=while basic amino acids react fastest with2 having an unsubstituted phenyl or a 4-formyl-phenyl Ar group. Amongst neutral amino acids, proline reacts fastest at room temperature after 100 min. With2 having a methoxy-subtituted Ar group.

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2 Open Chemistry

1 2010

1 2004

2 Draghici C.

1 Alexandru M.-G.

1 Balaban A.

1 Banciu M.

1 Bem M.

1 Beteringhe A.

1 Caproiu M.

1 Constantinescu T.

1 Grguric-Sipka S.

1 Jitaru I.

1 Vasilescu M.

1 Velickovic T.

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Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

Structural factors influencing the reaction rates of 4-aryloxy-7-nitrobenzofurazans with amino acids