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Molecular mechanisms of neoplasia

100%

Derkacz A., Komosińska-Vassev K.

Annales Academiae Medicae Silesiensis

2017

vol. 71

225-245

The evolution of normal cells into neoplastic cells involves many stages. This paper describes six characteristics of tumour cells: maintenance of cell division-promoting signals, resistance to exogenous growth inhibitors, avoidance of apoptosis, acquisition of the ability to undergo an infinite number of divisions, induction of angiogenesis as well as activation of the ability to invade and metastasise. The listed and described characteristics of tumor cells are associated with genomic instability and the production of inflammation. Genomic instability protes the formation of a diverse pool of cells, and the accumulation of traits of tumor cells leads to inflammation. The progress of science has enabled the addition of two further features acquired by cells during the process of neoplasia – modification of cellular metabolism and avoidance of recognition by the immune system.

Ewolucja komórki prawidłowej w nowotworową obejmuje wiele etapów. W pracy opisano sześć cech charakteryzujących komórki nowotworowe: utrzymanie sygnałów stymulujących podziały komórkowe, oporność na egzogenne inhibitory wzrostu, unikanie apoptozy, nabywanie zdolności do nieskończonej liczby podziałów, indukcję angiogenezy oraz aktywację zdolności do inwazji i przerzutowania. U podłoża wymienionych cech leży nie tylko niestabilność genomu promująca wytworzenie zróżnicowanej genetycznie puli komórek, ale także stan zapalny, który wymaga wystąpienia wielu cech charakterystycznych dla komórek nowotworowych. Postęp badań pozwolił dodać dwie kolejne cechy nabyte przez komórki w czasie nowotworzenia – modyfikację metabolizmu komórkowego oraz unikanie rozpoznania przez system immunologiczny.

THE INFLUENCE OF STORAGE TEMPERATURE AND UV-IRRADIATION ON FREE RADICAL SCAVENGING PROPERTIES OF ETHANOLIC EXTRACTS OF PROPOLIS

52%

Komosińska-Vassev K., Olczyk P., Ramos P., Mencner L., Derkacz A., Waluga E., Krysik K., Olczyk K., Pilawa B.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 74

issue 6

1833-1840

The free radical scavenging activity of ethanolic extracts of propolis (EEP) at the concentrations of 3%, 7%, and 10% was examined. The impact of storage temperature and exposure to ultraviolet (UV) light on the interactions of extracts of propolis with the model DPPH free radicals was also determined. The quenching of an X-band electron paramagnetic resonance spectra of DPPH free radicals by the extracts stored at room temperature, heated at the temperature of 50 oC and exposed to UV-irradiation, were compared. The examined propolis ethanolic extracts revealed an antioxidative character. The storage of the samples at a higher temperature (50 oC) caused a decrease of the scavenging activity equaling to 7% and 10% EEP. UV-irradiation of the 3% EEP increased the quenching of DPPH free radical lines. The reverse effect was observed for the 7% and 10% propolis extracts. The 3% ethanolic extract of propolis is more stable for storage at 50ºC, and less than other analyzed EEP susceptible for UV-irradiation. Alterations of the antioxidative properties of the analyzed EEP and changes in the kinetics of their interactions with free radicals, indicate that 3%, 7%, and 10% propolis extracts should not be exposed to the temperature of 50 oC and UV-irradiation.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 Annales Academiae Medicae Silesiensis

1 2018

1 2017

2 Derkacz A.

2 Komosińska-Vassev K.

1 Krysik K.

1 Mencner L.

1 Olczyk K.

1 Olczyk P.

1 Pilawa B.

1 Ramos P.

1 Waluga E.

Search results

Molecular mechanisms of neoplasia

THE INFLUENCE OF STORAGE TEMPERATURE AND UV-IRRADIATION ON FREE RADICAL SCAVENGING PROPERTIES OF ETHANOLIC EXTRACTS OF PROPOLIS