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1
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Expression of astroglial nerve growth factor in damaged brain

100%
Oderfeld-Nowak B., Bacia A.
Acta Neurobiologiae Experimentalis
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1994
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vol. 54
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issue 2
73-80
2
Content available remote

Trimethilin-induced plastic neuronal changes in rat hippocampus are accompanied be astrocytic trophic activity

81%
Koczyk D., Skup M., Zaremba M., Oderfeld-Nowak B.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 1
237-241
EN
Partial deafferentation of the hippocampus due to trymethyltin (TMT) intoxication has been reported to induce plastic rearrangements of neuronal elements but the factors that direct these responses are unknown. To assess the possible involvement of nerve growth factor (NGF) in the phenomenon we evaluated the presumable changes in the expression pattern of NGF immunoreactivity (NGF-IR) in rat hippocampus 21 days after administration of TMT (8 mg/kg, i.p.) when reactive changes are fully developed. Immunolabelling for TrkA known to mediate biological effects of NGF and for GFAP to identify astroglial cells as a one of presumed source of postinjury produced factors was carried out on adjacent sections to establish the relation between expression of these proteins. In control hippocampus NGF-IR and TrkA-IR were localized in neurons and/or nueropil. After exposure to TMT remarkable non-neuronal expression of both proteins was observed. The distribution pattern of NGF, TrkA and GFAP overlapped suggesting that reactive asrtocytes may not only produce NGF but also may become responsive to this neurotrophin. Zones of extensive NGF and TrkA astroglial expression corresponded to areas of axonal-dendritic rearrangements reported earlier. That data suggest that astroglia-derived trophic activity may be involved in neuronal plastic events associated with treatment with TMT.
3
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Difluoromethylornithine counteracts lesion-induced astrogliosis in rat hippocampus: enhancement of inhibitory effect by combined treatment with GM1 ganglioside

81%
Jaglinski W., Skup M., Zaremba M., Oderfeld-Nowak B.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 2
549-553
EN
The effect of difluoromethylornithine (DFMO), an irrevesible inhibitor of ornithine decarboxylase (ODC), the rate limiting enzyme of polyamine biosynthesis, and its combined action with GM1 ganglioside, was studied on the GFAP content in a model of remote astrogliosis evoked in the hippocampus by latral fimbria transection.DFMO markedly suppressed hipocampal gliosis as measured by GFAP immunoblotting seven days postsurgery.Combined treatment with DFMO and GM1 ganglioside produced a stronger suppressive effect than DFMO.The results support the hypothesis of a causal link between lesion induced events:polyamine biosynthesis and astroglial reaction.Potentation of the inhibitory effect of DFMO by GM1 ganglioside suggest that the latter does not act through the mechanism involving ODC suppression.
4
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Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways

61%
Skup M., Bacia A., Koczyk D., Jeglinski W., Zaremba M., Oderfeld-Nowak B.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 2
515-525
EN
Septal cholinergic neurones depend on trophic support by nerve growth factor (NGF) which can rescue them from injury-induced degeneration.Since NGF exerts its effects via p75NTR and TrkA receptors coexpressed in vast majority of these neurones and down-regulated without NGF treatment after injury.In this study we aimed to examine how does the lesion to the cholonergic tracts affect distribution of both type of receptor proteins in damaged fibres.Early changes (two and seven days) were examined immunocytochemically within the septum and supracallosal stria after unilateral lesion to the supracollosal area and cingulum transecting some septal cholinergic efferents.
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