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Sjogren's syndrome: immunological response underlying the disease

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Brayer J. B., Humphreys-Beher M. G., Peck A. B.

Archivum Immunologiae et Therapiae Experimentalis

2001

vol. 49

issue 5

353-360

Sjogren's syndrome is a chronic autoimmnune disorder characterized primarily by the discomforts od dry eyes and dry mouth due to the progressive loss of exocrine gland function. Development of a number of animal models to study Sjogren's syndrome, especially the NOD mouse and its congenic partner strains, has permitted a systematic analysis of immunological and non-immunological factors that influence predisposition for development of the autoimmune response. These data are reviewed here.

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1 Archivum Immunologiae et Therapiae Experimentalis

1 2001

1 Brayer J. B.

1 Humphreys-Beher M. G.

1 Peck A. B.

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Sjogren's syndrome: immunological response underlying the disease