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Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis

100%

Lisowska A., Kobelska-Dubiel N., Jankowska I., Pawłowska J., Moczko J., Walkowiak J.

2014

vol. 61

issue 1

103-107

Background & Aims: To date, no studies concerning the presence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis were published. Based upon characteristic of progressive familial intrahepatic cholestasis one can expect the coexistence of small intestinal bacterial overgrowth. The aim of the study was to assess the incidence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis. Methods: 26 patients aged 8 to 25 years with progressive familial intrahepatic cholestasis were included in the study. Molecular analysis of ABCB11 gene was performed in the vast majority of patients. In all patients Z-score for body weight and height, biochemical tests (bilirubin, bile acid concentration, fecal fat excretion) were assessed. In all patients hydrogen-methane breath test was performed. Results: On the basis of first hydrogen-methane breath test, diagnosis of small intestinal bacterial overgrowth was confirmed in 9 patients (35%), 5 patients (19%) had borderline results. The second breath test was performed in 10 patients: in 3 patients results were still positive and 2 patients had a borderline result. The third breath test was conducted in 2 patients and positive results were still observed. Statistical analysis did not reveal any significant correlations between clinical, biochemical and therapeutic parameters in patients with progressive familial intrahepatic cholestasis and coexistence of small intestinal bacterial overgrowth. Conclusions: Our results suggest that small intestinal bacterial overgrowth is frequent in patients with progressive familial intrahepatic cholestasis. Moreover, it seems that this condition has the tendency to persist or recur, despite the treatment.

Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans

84%

Walkowiak J., Bajerska J., Kargulewicz A., Lisowska A., Siedlerski G., Szczapa T., Kobelska-Dubiel N., Grzymisławski M.

2013

vol. 60

issue 3

481-483

Background & Aims: Green tea is known worldwide for its high content of polyphenolic compounds and multifactorial beneficial effects on human health. The role of green tea as an inhibitor of lipid hydrolysis is widely discussed. The aim of the study was to assess the influence of green tea extract on lipid digestion and absorption. Methods: The study comprised 32 healthy volunteers aged 23 to 30 years with normal exocrine pancreatic function. In all subjects 13C-labelled mixed triglyceride breath test was performed twice with and without green tea extract ingestion. Cumulative percentage dose recovery was considered to reflect digestion and absorption of lipids. Values are expressed as medians and 1st-3rd quartile distribution. Results: In all subjects, cumulative percentage dose recovery values were normal in a placebo test (36.8% <30.1-43.3%>). These results were significantly higher (p=0.021) than those obtained in green tea extract test (28.8% <23.1-37.2%>). Results of six tests with GTE were abnormal. Conclusions: Single dose of green tea extract taken with a test meal decreases lipid digestion and absorption in humans.

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2 Acta Biochimica Polonica

1 2014

1 2013

2 Kobelska-Dubiel N.

2 Lisowska A.

2 Walkowiak J.

1 Bajerska J.

1 Grzymisławski M.

1 Jankowska I.

1 Kargulewicz A.

1 Moczko J.

1 Pawłowska J.

1 Siedlerski G.

1 Szczapa T.

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Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis

Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans