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Significant involvement of chromosome 13q deletions in progression of larynx cancer, detected by comparative genomic hybridization

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Schlade-Bartusiak K., Stembalska A., Ramsey D.

Journal of Applied Genetics

2005

vol. 46

issue 4

407-413

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumours with various clinical characteristics. These tumours generally exhibit complex karyotypes. Few studies of genomic imbalances have been performed exclusively in subgroups of larynx cancer samples at different stages of the disease. In the present study, chromosomal gains and losses were investigated in 52 larynx tumours, by using comparative genomic hybridization (CGH). The mean number of observed alterations was 37.7 per tumour. The most common sites of losses were 1p, 13q, Xp, and the most common gains were located in 1p, 9q, 16q. The overall number of gains was negatively associated with cancer grading. G1 tumours were also characterized by a higher frequency of deletions in 13q32 and amplifications in 1q23, than tumours in other grades (p < 0.05). The frequency of losses of 13q22 also positively associated with tumour size. There was no association between the frequency of losses in 13q and the presence of lymph node metastases at the time of diagnosis. Another statistically significant association was observed for gains at 1q22-23 and tumour size (p < 0.01). No statistically significant difference in the frequency of most common imbalances was detected between primary tumours with lymph node metastases and those without metastases. In conclusion, we discovered a significant involvement of 13q deletions in the progression of larynx cancer. All the other significant changes observed in the present study were reported previously as being important for HNSCC progression. It seems that multiple genes are disrupted in the process of neoplastic transformation in the larynx, and the networks of events remain to be elucidated.

Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders

100%

Rymaszewska J., Ramsey D., Chladzinska-Kiejna S.

Archivum Immunologiae et Therapiae Experimentalis

2008

vol. 56

issue 1

63-68

Introduction: Rheumatism has been treated using whole-body cryotherapy (WBCT) since the 1970s. The aim of this study was to assess the efficacy of WBCT as an experimental, adjunctive method of treating depressive and anxiety disorders. Materials and Methods: A control (n=34) and a study group (n=26), both consisting of outpatients 18?65 years old with depressive and anxiety disorders (ICD-10), received standard psychopharmacotherapy. The study group was additionally treated with a series of 15 daily visits to a cryogenic chamber (2?3 min, from ?160?C to ?110?C). The Hamilton's depression rating scale (HDRS) and Hamilton's anxiety rating scale (HARS) were used as the outcome measures. Results: After three weeks, a decrease of at least 50% from the baseline HDRS-17 scores in 34.6% of the study group and 2.9% of the control group and a decrease of at least 50% from the baseline HARS score in 46.2% of the study group and in none of the control group were noted. Conclusion: These findings, despite such limitations as a small sample size, suggest a possible role for WBCT as a short-term adjuvant treatment for mood and anxiety disorders.

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1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Applied Genetics

1 2008

1 2005

2 Ramsey D.

1 Chladzinska-Kiejna S.

1 Rymaszewska J.

1 Schlade-Bartusiak K.

1 Stembalska A.

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Significant involvement of chromosome 13q deletions in progression of larynx cancer, detected by comparative genomic hybridization

Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders