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1

Prostaglandins and the kidney

100%
Senatorski G., Paczek L., Lac M.
Postępy Higieny i Medycyny Doświadczalnej
|
1993
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vol. 47
|
issue 5
305-324
2

The role of proteolytic enzymes in pathogenesis of primary glomerulonephritides

100%
Senatorski G., Paczek L., Gradowska L.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
|
vol. 51
|
issue 2
139-148
EN
There are many evidences that nonimmunologic factors contribute to pathogenesis of primary glomerulonephritides. Proteolytic enzymes plays important role in glomerular protein turn-over and their altered activities may have influence on glomerular function. The purpose of this paper was to review the role of proteolytic enzymes in initiation and progression of idiopathic glomerular diseases.
3

Involvement of beta2-microglobulin in CD69 expression on T cells

76%
Paczek L., Czarkowska-Paczek B., Korczak-Kowalska G., Wierzbicki P., Bartlomiejczyk I., Gorski A.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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vol. 49
|
issue 3
239-242
EN
Beta2-Microglobulin (beta2M) is the light chain of the class I HLA molecule. The serum level of beta2M is elevated in various diseases including lymphoma, inflammation, viral infections and chronic renal dysfunction. The present study addressed the possible influence of beta2M on T lymphocyte activation in vitro. Peripheral blood mononuclear cells from a group of 17 healthy subjects were examined. Stimulation with OKT3 and fibronectin in combination with 30 mg beta2M/dl resulted in a two-fold increase of cell proliferation. A similar effect was observed when OKT3 and collagen I were applied as well as when OKT3 and collagen IV were used as costimulation to T cells. The CD69 expression, measured by flow cytometry was significantly enhanced above the control level (1.52 ? 1.03% vs 33.21 ? 20.26%, p<<0.01, control group and 30 mg beta2M/dl, respectively). Together, these observations suggest that beta2M may play a role in modulating lymphocyte proliferation, possibly through modification of the CD69 molecule.
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