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Unusual case of calciphylaxis associated with digital necrosis and penile necrosis

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Uygur F., Sever C., Noyan N., Küçükodaci Z.
Open Medicine
|
2009
|
vol. 4
|
issue 3
391-394
EN
Calciphylaxis is a relatively rare disorder associated with calcification of small- and medium-sized blood vessels, progressive ischemic skin necrosis, and ulcerations. This situation is a potentially life-threatening condition seen in patients with endstage renal disease (ESRD). A 64-year-old man with ESRD on dialysis for 6 years was admitted to our clinic with severe pain and partial necrosis of some fingers on his right hand. In addition, the patient had suffered from diabetes for 22 years and had been on insulin therapy for 17 years. His necrotic fingers were amputated. After two months, necrosis on his glans penis developed despite medical management. Penile amputation was performed. In this case report, the patient serves to illustrate the spectrum of complications with which calciphylaxis can be associated.
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The current analysis of the effect of hyperbaric oxygen therapy on the frostbitten tissue: Experimental study in rabbits

100%
Uygur F., Noyan N., Sever C., Gümüş T.
Open Medicine
|
2009
|
vol. 4
|
issue 2
198-202
EN
Many experimental studies have been performed and the mechanism of hyperbaric oxygen therapy on the frostbitten tissue has not been elucidated. In this study, we evaluated the effect of hyperbaric oxygen therapy on the frostbitten ears of rabbits in an experimental animal model by examining the concentrations of thromboxane A2 (as thromboxane B2-Tx B2) and of prostaglandin I2 (PG I2) (as 6-keto-prostaglandin F1α-PG F1α) in tissues, and by counting the numbers of inflammatory cells (neutrophils and mast cells-MC) Hyperbaric oxygen therapy (HBO) at 2.5 ATA for 90 minutes twice daily for fourteen days to rabbits, the ears of which were subjected to frostbite, decreased presence of inflammatory cells (mast cells −75%; neutrophils −40%) and increased prostaglandin I2 (PG I2) (as 6-Keto-PGF1α) in the involved skin. Thromboxane A2 (TxA2) (as Tx B2) was unaffected. Our results revealed that an inflammatory process was the underlying cause of frostbite injury and that hyperbaric oxygen therapy was active in pathological situations involving an inflammatory process in frostbite.
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