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Fluoride bioavailability in saliva using DENTTABS® compared to dentifrice

100%
Naumova E., Arnold W., Gaengler P.
Open Medicine
|
2010
|
vol. 5
|
issue 3
375-380
EN
It was the aim of this study to assess fluoride retained in saliva after use of fluoride-containing tablet DENTTABS® compared to toothpaste containing amine fluoride. Four subjects (2 normal saliva secretors, 1 slow secretor, and 1 fast secretor) participated in this crossover study comparing DENTTABS® and ELMEX®. After baseline sample collection, calibrated study personnel brushed the subjects’ teeth with the assigned product for 3 minutes. Saliva samples were taken at baseline (T0), immediately after brushing (T1) and then 10 (T2), 25 (T3) and 85 (T4) minutes post-brushing. The amount of saliva collected was measured, and the fluoride content was analysed. All 4 subjects repeated all study cycles 5 times. Statistical analysis was done using the Mann-Whitney-U test and Spearman correlation. The fluoride retention was significantly higher after brushing with DENTTABS® at T1 and T2. There was a correlation between individual salivary flow rate and the F- content. Flow rate in g/min ranged from 1.1 to 3.8 at T1 and from 0.2 to 1.1 at T4 with much higher F- retention in slow secreting cycles. The saliva fluoride clearance kinetics of two equal amounts of fluoride-containing oral hygiene products demonstrate higher retention for DENTTABS®.
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Fluoride bioavailability in saliva during acute psychological stress

64%
Naumova E., Sandulescu T., Benson S., Engler H., Schedlowski M., Zimmer S., Gaengler P., Thie M., Arnold W.
Open Medicine
|
2012
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vol. 7
|
issue 4
481-489
EN
The aim of this study was to investigate the influence of acute stress on salivary fluoride bioavailability. Acute psychological stress was induced using a standardized model of public speaking. The saliva of male subjects was collected before and after the public speaking task and immediately, 10, 30, and 120 minutes after tooth brushing according to the Bass method with a dentifrice containing amine fluoride (AmF) or oral hygiene tablets containing sodium fluoride (NaF). Subjective psychological responses to public speaking were evaluated using the State-Trait Anxiety Inventory (STAI). Saliva cortisol levels were analyzed as an objective stress marker. The saliva secretion rate was measured both before and after public speaking. Saliva fluoride content was measured. Group comparisons were calculated using a univariate analysis of variance (ANOVA). In all analyses, the alpha-level was set at 0.05. Public speaking significantly increased state anxiety (p<0.001) and salivary cortisol concentrations (p<0.001). Acute stress did not influence salivary secretion rates. In the AmF group, stressed individuals exhibited statistically significant (p=0.044) lower fluoride concentration in saliva compared with the nonstressed subjects Acute psychological stress reactions do not cause hyposalivation but decrease fluoride bioavailability after using a dentifrice containing AmF. Fluoride bioavailability during acute stress is dependent on fluoride formulation.
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