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EN
The anisotropic g factors g_{∥} and g_{⊥} of La_2Ni_{0.5}Li_{0.5}O_4 are theoretically investigated using the perturbation formulae of the g factors for a low spin (S=1/2) 3d^7 ion in tetragonally elongated octahedra. The studied Ni^{3+} (3d^7) center arises from the original Ni^{2+} capturing one hole by Li^{+} doping. The positive anisotropy Δ g (= g_{⊥}-g_{∥}) can be ascribed to the lowest ^2 A_{1g} state due to the obvious (about 0.14 Å) tetragonal elongation of the oxygen octahedron around the Ni^{3+} site via the Jahn-Teller effect, and the effective magnetic moment is also interpreted in a uniform way. The calculated results show good agreement with the experimental data, and the imperfection of the previous studies based on various adjusted tetragonal energy splittings without correlating to the local structure of the magnetic center is thus overcome in this work.
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issue 5
307-315
EN
Nucleic acid aptamers are short, single-stranded oligonucleotides or their modified analogues which avidly and specifically interact with targeted ligands through their 3-dimensional structure. Aptamers can be selected out of a large combinatorial oligonucleotide library through an in vitro evolution process termed SELEX. Since 1990, a wide variety of aptamers targeted to ligands ranging from small molecules to complex mixtures have been isolated. Most selected aptamers have shown high specificity to and affinity for their ligands and are potential detection and/or diagnostic reagents. Furthermore, some aptamers specifically inhibit biological functions of targeted proteins, resulting in potent therapeutic candidates in disease models. Some recent advances to increase the stability of aptamers, extend their in vivo circulation time and their in vivo expression have pushed aptamers closer to therapeutic applications. This review presents recent developments in the field of aptamer research and focuses on their applications to human viral diseases, particularly HIV induced diseases.
EN
The invariants for the time-dependent one-dimensional harmonic oscillator and the time-dependent two-dimensional harmonic oscillator in a static magnetic field are derived from the real representation of the exact solution to the equation of motion. Mathematically, the orthogonal functions invariant is the angular momentum of an isotropic time-dependent two-dimensional harmonic oscillator. Based on the invariants obtained here, the wave function for time-dependent two-dimensional harmonic oscillator in a static magnetic field in cylindrical coordinate is simply derived and the dynamical and geometrical phases are easily got by expressing the wave function as the superpositions of the wave functions of time-dependent two-dimensional harmonic oscillator in rectangular coordinate. For the driven system, the driving induced dynamical phase and the geometrical phase are respectively associated with the classical Hamiltonian and de Broglie wave of the center motion of the wave function.
EN
Transport of Brownian particle moving along a three-dimensional throat-like channel is investigated in the presence of an external constant force. The solution of the Fick-Jacobs equation in the situation is solved, and the probability current density and particle current describing the motion of particle are obtained. It is found that entropy barrier and external force can reverse the direction of particle current. The motion of Brownian particle can be tuned by the entropy barrier and the external force.
EN
Exosomes are small membrane vesicles derived from late endosome. They are about 30?100 nm in diameter. The secretion of exosomes is a process in which multivesicular bodies fuse with the cell membrane, and all cells that contain multivesicular endocytic compartments could theoretically secrete exosomes. The surprising biological functions of exosomes are only slowly being unveiled, but it is already clear that they serve to remove obsolete membrane proteins and act as messages of inter-cellular communication. Exosomes derived from tumor or antigen-presenting cells have been extensively investigated. They are released into the extracellular environment and fuse with the membranes of neighboring cells, delivering membrane and cytoplasmic proteins from one cell to another. Exosomes carry immunorelevant structures which play important roles in immune response, such as MHC molecules, costimulatory molecules, heat shock proteins, and naive tumor antigens. Therefore they have been suggested as potential vaccines. Consequently, exosomes have shown considerable anti-tumor effect in several studies and are in phase I clinical trials.
EN
The spin Hamiltonian parameters (g factors g_{∥ }, g_{⊥} and the hyperfine structure constants A_{∥ }, A_{⊥}) and the local structures for the two tetragonal Cu^{2+} centers I and II in Ca(OH)_2 are theoretically studied from the perturbation formulae of these parameters for a 3d^9 ion under tetragonally elongated octahedra. The [Cu(OH)_6]^{4-} clusters on the substitutional Ca^{2+} site are found to suffer the relative elongations by about 0.083 Å and 0.065 Å for centers I and II, respectively, along the C_4 axis due to the Jahn-Teller effect. The above tetragonal elongations may entirely depress the original trigonal distortion of the host Ca^{2+} site in Ca(OH)_2. The calculated spin Hamiltonian parameters based on the above Jahn-Teller elongations show good agreement with the experimental results. The EPR spectra and the local structures for the two centers are compared with one another.
EN
Barley yellow dwarf virus (BYDV) can cause significant losses of wheat worldwide. The long arm segment of Thinopyrum intermedium chromosome 7Ai#1 carrying the BYDV resistance gene Bdv2 was translocated to the distal region of the long arm of wheat chromosome 7D in translocation line Yw642. In this study, 40 wheat EST sequences located in the distal region of 7DL were explored to identify specific PCR markers for the Bdv2 region on the basis of the homoeologous relationship between wheat chromosome 7D and Th.intermedium chromosome 7Ai#1. Our results revealed 8 novel EST-PCR markers specific to the Bdv2 region, including 5 EST-STS markers of BE404744, BE498985, BE591497, BG606695 and BQ161842, and 3 EST-SSCP markers of BE404953, BG312663 and BE498985. These EST-PCR markers could distinguish Bdv2 from another BYDV-resistance gene located on Th.intermedium chromosome 2Ai-2. These specific bands for the Bdv2 region were further cloned and sequenced. The sequencing analysis indicated that the specific sequences for the Bdv2 region were highly homologous with the original wheat EST sequences that were used to design primers, and encode respectively a protein kinase, P450, centrin, transducin, and a hypothetical protein. This study created a starting point for eventual cloning of the Bdv2 gene and understanding the defense mechanism.
EN
Winter wheat cultivars Aquileja (AQ) and Xian Nong 4(XN) were previously reported to possess durable, quantitative resistance to stripe rust disease. In the present study, AQ, XN and a susceptible wheat cultivar were reciprocally crossed in all 6 combinations. Parents, F1, F2, F3, BCP1 and BCP2 were used to determine quantitative genetic parameters for infection type and disease severity. The results showed that fixable genetic components preponderated in the inheritance of the resistance in AQ and XN for both infection type and disease severity, while the dominant component could be detected in some cases. The resistance was conditioned by oligogenes. Heritability of the resistance ranged from 50 to 79% in most cases.
EN
Winter wheat cultivars Aquileja (AQ) and Xian Nong 4(XN) were previously reported to possess durable, quantitative resistance to stripe rust disease. In the present study, AQ, XN and a susceptible wheat cultivar were reciprocally crossed in all 6 combinations. Parents, F1, F2, F3, BCP1 and BCP2 were used to determine quantitative genetic parameters for infection type and disease severity. The results showed that fixable genetic components preponderated in the inheritance of the resistance in AQ and XN for both infection type and disease severity, while the dominant component could be detected in some cases. The resistance was conditioned by oligogenes. Heritability of the resistance ranged from 50 to 79% in most cases.
EN
Charging operations of a compact Tesla transformer were experimentally investigated, in single-shot and rep-rate (50 pps for 1 s) modes, respectively. The charging limitations were also explored. The experimental results were compared and analyzed. The maximum secondary charging voltages of the Tesla transformer were measured to be 380 kV and 300 kV in single-shot and rep-rate modes, respectively. The RMS pulse-to-pulse instability of the secondary charging voltage is generally less than 10% but increases with the increasing initial voltage across the primary capacitor. Since the secondary capacitor of the Tesla transformer is a pulse forming line (PFL), continued operation is possible if there is breakdown in the PFL. Furthermore, operation can even be continued under occasional breakdown for some pulses, without the effects on the operations of subsequent pulses.
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