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Statins and hemoperfusion improve 28-day survival in septic shock patients

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Nakamura T., Sato E., Fujiwara N., Kawagoe Y., Maeda S., Inoue H., Yamagishi S.-i.

Open Medicine

2012

vol. 7

issue 4

475-480

Uncontrolled inflammation and endotoxin play a central role in septic shock. Statins may possess anti-inflammatory properties, and removal of endotoxin by hemoperfusion with polymyxin B-immobilized fiber (PMX-F) could have favorable effects on sepsis. We examined retrospectively whether pre-existing statin and hemoperfusion with PMX-F at the time of admission were separately and independently associated with decreased overall 28-day mortality in septic shock patients. Consecutive 173 patients with septic shock (71.2±10.7 years old, 115 male and 58 female) were included in the present study. All patients underwent a complete history and physical examination, determination of blood chemistries. Multiple stepwise regression analysis revealed that albumin, creatinine (inversely), statin use, hemoperfusion with PMX-F and HDL-cholesterol were independently correlated to 28-day survival in septic shock patients (R2=0.464). Our present study suggests that pre-existing statin use and hemoperfusion with PMX-F may separately and independently contribute to blunt the process of septic shock.

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1 Open Medicine

1 2012

1 Fujiwara N.

1 Inoue H.

1 Kawagoe Y.

1 Maeda S.

1 Nakamura T.

1 Sato E.

1 Yamagishi S.-i.

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Statins and hemoperfusion improve 28-day survival in septic shock patients