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  1. 1 Biotechnologia

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  1. 1 1996

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  1. 1 Missol E.

  2. 1 Sochanik A.

  3. 1 Szala S.

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The use of E.coli cytosine deaminase gene as an example of suicide gene therapy of cancer

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Missol E., Sochanik A., Szala S.
Biotechnologia
|
1996
|
issue 4
80-90
EN
Suicide genes encode enzymes, which convert nontoxic substrates to toxic products.These genes are proposed for selective killing of tumor cells in cancer gene therapy.In this review we demonstrate preliminary results of direct in vivo transfer of cytosine deaminase (CD) gene from E.coli into murine B16(F10) melanoma cells via cationic liposomes.
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