Search results

1

Dr Jerzy Domalski (1944-2006)

100%

Bielecki K.

Polish Journal of Surgery

|

2008

|

vol. 80

|

issue 1

54-55

2

Left-Handed Surgeons

81%

Klukowski M., Wierzchowska A., Bielecki K.

Polish Journal of Surgery

|

2007

|

vol. 79

|

issue 6

461-463

3

Results of Surgical Treatment of Colorectal Cancer in Octogenerians Patients

81%

Tarnowski W., Kamiński P., Bielecki K.

Polish Journal of Surgery

|

2010

|

vol. 82

|

issue 7

410-416

EN

The aim of the study was to estimate factors affecting results of surgical treatment of colorectal cancer in octogenarian patients in comparison with a group of younger patients.Material and methods. Hospital records were reviewed prospectively and data were collected from a consecutive series of 1021 patients operated on because of primary colorectal cancer between 1988 and 2009.Results. One hundred sixteen patients aged minimum 80 years of life were identified with an average age of 83.6 years. They were compared with 905 younger patients with an average age of 61.9 years. Co-morbidity, presentation in ASA 2, ASA 3 and ASA 4 score were significantly higher in octogenarian than in younger patients group. Emergent operations were performed significantly more often in octogenerians than in younger patients as well (31% versus 14% respectively). Resection of cancer and primary bowel anastomosis was performed less often in patients aged over 80 years than in younger patients (58.6% versus 70.9% respectively). Postoperative complications rate was significantly higher among the older than younger patients (43.9% versus 30.7% respectively). Mortality was higher in older than in younger patients (22.4% vs 5.7% respectively).Conclusions. Results of surgical treatment of colorectal cancer in octogenarian patients are affected by higher co-morbidity and more often presentation of ASA 3 and ASA 4 score than in younger patients. Surgical treatment of colorectal cancer in octogenarians is burdened with higher rate of postoperative complications and almost four times higher mortality rate than in younger patients.

4

Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats

42%

Krześniak N., Paziewska A., Rubel T., Skrzypczak M., Mikula M., Dzwonek A., Goryca K., Wyrwicz L. S., Jarosz D., Laubitz D., Woszczyński M., Bielecki K., Ostrowski J.

|

2011

|

vol. 58

|

issue 1

79-87

EN

Colon anastomosis is therapeutically challenging because multiple, usually undetectable factors influence a spectrum of repair mechanisms. We hypothesized that low molecular weight heparins, routinely administered perioperatively, may differentially affect gene expression related to colon healing. Twenty pairs of untreated and enoxaparin-treated rats underwent left-side hemicolectomy with a primary end-to-end anastomosis. Normal colon and anastomotic bowel segments were resected on day 0 and on days 1, 3, 5, and 7 after surgery, respectively. Serial anastomosis transverse cross-sections were evaluated microscopically and by microarray (Rat Genome 230 2.0, Affymetrix). Differentially expressed probe sets were annotated with Gene Ontology. We also examined the influence of enoxaparin on fibroblast proliferation and viability in vitro. Among the 5476 probe sets, we identified differential expression at each healing time point, yielding 79 subcategories. Most indicated genes were involved in wound healing, including multicellular organismal development, locomotory behavior, immune response, cell adhesion, inflammatory response, cell-cell signaling, blood vessel development, and tissue remodeling. Although we found no intensity differences in histological features of healing between enoxaparin-treated and control rats, treatment did induce significant expression changes during early healing. Of these changes, 83 probe sets exhibited at least twofold changes and represented different functional annotations, including inflammatory response, regulation of transcription, regulation of apoptosis, and angiogenesis. Fibroblast culture confirmed an anti-viability effect of enoxaparin. Enoxaparin affects colon wound-related gene expression profiles, but further studies will resolve whether heparin treatment is a risk factor after intestinal surgery, at least in some patients.

5

Polish Consensus Statement On The Protective Stoma

33%

Szczepkowski M., Banasiewicz T., Krokowicz P., Dziki A., Wallner G., Drews M., Herman R., Lorenc Z., Richter P., Bielecki K., Tarnowski W., Kruszewski J., Kładny J., Głuszek S., Zegarski W., Kielan W., Paśnik K., Jackowski M., Wyleżoł M., Stojcev Z., Przywózka A.

Polish Journal of Surgery

|

2015

|

vol. 86

|

issue 8

391-404

Refine search results

Dr Jerzy Domalski (1944-2006)

Left-Handed Surgeons

Results of Surgical Treatment of Colorectal Cancer in Octogenerians Patients

Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats

Polish Consensus Statement On The Protective Stoma