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To predict the determinants of severity of COVID-19 illness in a tertiary care hospital.

100%

Sule S., Khatal S., Paramshetti B., Sawarthia S.

Critical Care Innovations

2023

vol. 6

issue 2

10-22

Retrospective comparative study of clinical profile and pulmonary involvement in unvaccinated and vaccinated individuals diagnosed with COVID-19

88%

Dasgupta S., Patil P., Barsode S., Paramshetti B., Akula U. K.

INTRODUCTION: This study aims to assess the clinical profile, co-morbidities and pulmonary involvement by means of CT-SS and CO-RADS in unvaccinated and completely vaccinated individuals diagnosed with COVID-19 infection. MATERIAL AND METHODS: A total of 138 adult patients infected with SARS-CoV-2 Virus between January 2021 and January 2022 in Bharati Hospital and Research Centre, Pune, Maharashtra, India were recruited for this retrospective, comparative study. Data was collected from medical records. All patients presenting to the institute with clinical features suggestive of SARS-CoV-2 infection were subjected to confirmative testing and the patients who tested positive for SARS-CoV-2 infection underwent a standardized HRCT thorax imaging. Clinical features, comorbidities, vital parameters and the association of CTSS scores and CO-RAD scores between vaccinated and unvaccinated individuals were analyzed. RESULTS: Out of the 138 patients included in this study, 69 (39 male, 30 female) were unvaccinated and 69 (49 male, 20 female) were vaccinated. Mean CO-RADS and CTSS in the unvaccinated cohort was significantly higher than the vaccinated (p <0.001). Mean CO-RADS = 5.14 (unvaccinated) vs 3.72 (vaccinated) and mean CTSS = 15.23 (unvaccinated) vs 10.54 (vaccinated). Patients with no co-morbidities had significantly lower CTSS and CORADS scores, regardless of vaccination status. Vaccinated patients suffered from mild disease, as noted by lower requirement of supplemental oxygen, higher SpO2 on room air, and lower incidence of nonspecific symptoms, respiratory symptoms, and gastrointestinal symptoms. CONCLUSIONS: This study finds that complete vaccination is necessary in order to prevent severe symptoms, high oxygen requirement, and extensive pulmonary involvement in COVID-19.

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2 Critical Care Innovations

2 2023

2 Paramshetti B.

1 Akula U. K.

1 Barsode S.

1 Dasgupta S.

1 Khatal S.

1 Patil P.

1 Sawarthia S.

1 Sule S.

Search results

To predict the determinants of severity of COVID-19 illness in a tertiary care hospital.

Retrospective comparative study of clinical profile and pulmonary involvement in unvaccinated and vaccinated individuals diagnosed with COVID-19