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Lectin histochemistry and alkaline phosphatase activity in the pia mater vessels of spontaneously hypertensive rats (SHR)

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Szumanska G., Gadamski R.

Neuropatologia Polska

1992

vol. 30

issue 2

99-110

Some lectins were used to study the localization of sugar residues on the endothelial cell surface in the pia mater vessels of control (WKY) and hypertensive rats (SHR). The lectins tested recognized the follwing residues: beta-D-galactosyl (Ricinus communis agglutinin 120, RCA-1), alpha-L-fucosyl (Ulex europaeus agglutinin, UEA-1), N-acetylglucosaminyl and sialyl (Wheat germ agglutinin, WGA), N-glocyl-neuraminic acid (Limax flavus agglutinin, LFA) and N-acetyl-D-galactosaminyl (Helix pomatia agglutinin, HPA). Several differences were revealed in the presence of sugar receptors on the surface of endothelial cells between the control and the hypertensive rats. Our studies showed also differences in the localization of the tested glycoconjugates between pial capillaries, small,medium-size and large pial arteries. The histochemical evaluation of alkaline phosphatase revealed an increased activity of the enzyme in the pial vessels of SHRs as compared with control rats, with a similar localization of the enzyme activity. Some differences in the distribution of lectin binding sites and alkaline phosphatase activity could be associated with the different functions of particular segments of the pial vascular network.

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1 Neuropatologia Polska

1 1992

1 Gadamski R.

1 Szumanska G.

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Lectin histochemistry and alkaline phosphatase activity in the pia mater vessels of spontaneously hypertensive rats (SHR)