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Unusual case of calciphylaxis associated with digital necrosis and penile necrosis

100%
Uygur F., Sever C., Noyan N., Küçükodaci Z.
Open Medicine
|
2009
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vol. 4
|
issue 3
391-394
EN
Calciphylaxis is a relatively rare disorder associated with calcification of small- and medium-sized blood vessels, progressive ischemic skin necrosis, and ulcerations. This situation is a potentially life-threatening condition seen in patients with endstage renal disease (ESRD). A 64-year-old man with ESRD on dialysis for 6 years was admitted to our clinic with severe pain and partial necrosis of some fingers on his right hand. In addition, the patient had suffered from diabetes for 22 years and had been on insulin therapy for 17 years. His necrotic fingers were amputated. After two months, necrosis on his glans penis developed despite medical management. Penile amputation was performed. In this case report, the patient serves to illustrate the spectrum of complications with which calciphylaxis can be associated.
2
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The combined use of the nasal prosthesis with nasal stents

100%
Günay Y., Uygur F., Atay A., Çeliköz B.
Open Medicine
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2010
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vol. 5
|
issue 2
257-260
EN
Severe and composite defects of the nose due to trauma or excision of neoplasms can cause significant functional and aesthetic problems. It has been known that nasal stents have been used to maintain the nasal patency and nostril shape for a long time. Recently, nasal prosthesis was introduced as a method to solve aesthetic problems of the patients who had an amputated nose. In the present study, nasal prosthesis combined with nazal stents was used to camouflage the nasal disfigurement and to maintain the nasal patency in two adult female patients. Functional and aesthetic results was accepted as satisfactory by both the patients and the physicians.
3
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The use of reverse-flow dorsal metacarpal artery flaps after postburn metacarpophalangeal joint flexion contracture release

100%
Duman H., Uygur F., Evinç R.
Open Medicine
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2010
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vol. 5
|
issue 2
159-164
EN
When thermal injuries of the hand are managed inappropriately, complex hand contractures are inevitable. Patients with hand contractures may have many difficulties in their daily life because of this deformity. These patients are challenging to reconstructive surgeons. In this study we evaluated reverse-flow dorsal metacarpal artery flaps for the defects occurred after metacarpophalangeal joint contracture release of different fingers. Nineteen patients with defects on the volar surface of metacarpophalangeal joint were reconstructed by the reverse-flow dorsal metacarpal artery flaps. All operations were successful and flap losses were not seen. The DMCA flaps provide one stage coverage and permit primary closure of the recipient site. The aesthetic and functional results are satisfactory without sacrificing main arteries. The only drawback is the residual scar on the dorsum of the hand, which can be treated by conservative means and may improve over time.
4
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The current analysis of the effect of hyperbaric oxygen therapy on the frostbitten tissue: Experimental study in rabbits

100%
Uygur F., Noyan N., Sever C., Gümüş T.
Open Medicine
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2009
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vol. 4
|
issue 2
198-202
EN
Many experimental studies have been performed and the mechanism of hyperbaric oxygen therapy on the frostbitten tissue has not been elucidated. In this study, we evaluated the effect of hyperbaric oxygen therapy on the frostbitten ears of rabbits in an experimental animal model by examining the concentrations of thromboxane A2 (as thromboxane B2-Tx B2) and of prostaglandin I2 (PG I2) (as 6-keto-prostaglandin F1α-PG F1α) in tissues, and by counting the numbers of inflammatory cells (neutrophils and mast cells-MC) Hyperbaric oxygen therapy (HBO) at 2.5 ATA for 90 minutes twice daily for fourteen days to rabbits, the ears of which were subjected to frostbite, decreased presence of inflammatory cells (mast cells −75%; neutrophils −40%) and increased prostaglandin I2 (PG I2) (as 6-Keto-PGF1α) in the involved skin. Thromboxane A2 (TxA2) (as Tx B2) was unaffected. Our results revealed that an inflammatory process was the underlying cause of frostbite injury and that hyperbaric oxygen therapy was active in pathological situations involving an inflammatory process in frostbite.
5
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Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats

76%
Uygur F., Özyurt M., Evinç R., Hosbul T., Çeliköz B., Haznedaroglu T.
Open Medicine
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2008
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vol. 3
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issue 4
417-421
EN
Pseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride (Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon iodine (Betadine, Purdue Pharma L.P, Stamford, USA) were compared to assess the antiseptic effect of their applications on experimental burn wounds in in rats contaiminated with P. aeruginosa. All treatment modalities were effective against P. aeruginosa because there were significant differences between treatment groups and control groups. The mean eschar concentrations were not different between polyhexanide and povidon iodine groups, but there were significant differences between the octenidine dihydrochloride group and the other treatment groups, indicating that the Octenidine dihydrochloride significantly eliminated P. aeruginosa more effectively in the tissues compared to the to other agents. All treatment modalities were sufficient to prevent the P. aeruginosa invasion into the muscle and to cause systemic infection. In conclusion, Octenidine dihydrochloride is the most effective antiseptic agent in the treatment of the P. aeruginosa-contaminated burn wounds; Octenidine dihydrochloride can be considered as a treatment choice because of its peculiar ability of limit the frequency of replacing wound dressings.
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