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Vaccination in children with cancer: a debate

100%
Battista A., Ruggiero A., Coccia P., Arena R., Attinà G., Riccardi R.
Open Medicine
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2012
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vol. 7
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issue 2
137-141
EN
Children with malignancy present an important alteration of the immune system functionality caused by the illness itself and by the therapy they undergo. Therefore, they are at high risk of contracting vaccine-preventable diseases and of developing important complications. Vaccinations represent valid devices against these infections but this condition involves two main problems: are vaccines safe in these patients? Are vaccines effective in these patients? The aim of this review is to discuss the principles of vaccination management in children with cancer.
2
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Chronic Idiopathic Thrombocytopenic Purpura in children: predictive factors and outcome

84%
Coccia P., Ruggiero A., Attinà G., Cerchiara G., Battista A., Arena R., Scalzone M., Puma N., Ridola V., Riccardi R.
Open Medicine
|
2012
|
vol. 7
|
issue 4
525-528
EN
Idiopathic thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia in children. In 20% of cases, this condition is classified as chronic when the thrombocytopenia is persistent 6 months after diagnosis. The aim of the present study is to identify the potential factors correlating with a favorable outcome in patients with chronic ITP. Some 71 patients affected by ITP were retrospectively analyzed. Results show a higher rate of spontaneous recovery that is statistically significant for patients with platelet count at diagnosis <20,000/µL. These observations suggest the possibility to delay or avoid aggressive surgical treatment for these patients.
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