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1,3-OXAZOLIDIN-5-ONES DERIVED FROM PROLINE AS CHIRAL COMPONENTS IN THE SYNTHESIS OF PREDICTIVE ENANTIOSELECTIVE COUPLING REAGENTS

100%

Kasperowicz-Frankowska K., Kolesińska B., Gzik A., Jastrząbek K., Kaminski Z. J.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 4

921-927

1,3-Oxazolidin-5-ones derived from both enantiomers of proline and trichloroacetaldehyde were prepared and applied as amine component in the synthesis of chiral predictive triazine based coupling reagents. The usefulness of these reagents in the condensations yielding enantiomerically enriched products from racemic substrates was presented.

Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose

73%

Fraczyk J., Walczak M., Balcerzak W., Pokajewicz K., Wieczorek P., Młynarski W., Fendler W., Kaminski Z. J.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 4

1017-1029

A novel diagnostic method based on recognition of qualitative and quantitative composition of healthy and tumor tissue samples by library of molecular receptors was presented. Molecular receptors were formed by self-organization of N-lipidated peptides attached in the regular fashion via aminophenylamino-1,3,5-triazine linker to the surface of cellulose plate. For samples testing, the library was cloned into multiple, identical copies and for each experiment the new clone was used. The binding process was monitored by staining the discs with Brilliant Black and quantitative color measurement was performed in 256 grade gray scale. Substantial differences in the composition of healthy and tumor samples were observed in most cases. The highly individual chemical fingerprints were found to be reliant on the cancer type. For malignant papillary thyroid cancer statistical analysis identified two receptors most useful for diagnostic purposes.

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2 Acta Poloniae Pharmaceutica - Drug Research

2 2018

2 Kaminski Z. J.

1 Balcerzak W.

1 Fendler W.

1 Fraczyk J.

1 Gzik A.

1 Jastrząbek K.

1 Kasperowicz-Frankowska K.

1 Kolesińska B.

1 Młynarski W.

1 Pokajewicz K.

1 Walczak M.

1 Wieczorek P.

Search results

1,3-OXAZOLIDIN-5-ONES DERIVED FROM PROLINE AS CHIRAL COMPONENTS IN THE SYNTHESIS OF PREDICTIVE ENANTIOSELECTIVE COUPLING REAGENTS

Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose