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The effects of immunosuppressive agents on inflammatory response in septic rats

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Filiz A., Ozturk A., Kurt Y., Sucullu I., Akin M., Yildiz M.
Open Medicine
|
2010
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vol. 5
|
issue 6
683-690
EN
Sepsis remains a serious clinical problems resulting in high morbidity and mortality. We aimed to investigate the inflammatory response in a septic rat model treated with immunomodulator agents. We used the cecal ligature and puncture model to establish septic peritonitis in rats. Male Wistar-Albino rats were randomized into groups of seven rats each and assigned different regimens: Tacrolimus 1 mg/kg/day, cyclosporin-A 5 mg/kg/day and methylprednisolone 15 mg/kg/day. These immunsuppressive agents were applied at the 6 and 48 hour intraperitoneally. The animals were euthanized after 6 and 48 hours and systemic parameters including, IL-2, IL-6, TNF-a, CRP, AST and creatinine were examined. Our study demonstrated that the experimental peritonitis model caused a meaningful rise in the values of systemic parameters. This was especially apparent for early-applied cyclosporin A; in addition, tacrolimus significantly decreased the levels both at the 6 and 48 hour. The excess immune response in complex sepsis treatment might be restrained using immunosuppressive agents administered early. Although additional supportive, comprehensive, experimental and clinical studies are still needed, this therapy model may prove to be an alternative for the future.
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Seminoma presented with acute abdomen due to ileum perforation

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Filiz A., Sücüllü İ., Kurt Y., Okul O., Küçükodaci Z., Karagöz B.
Open Medicine
|
2010
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vol. 5
|
issue 5
636-639
EN
Germ cell tumors presenting with an acute abdomen are not common. We present a case of seminoma with ileum perforation, which presented in a 48-year-old man. who had been admitted to hospital with a right lower abdominal palpable mass measuring approximately 16 cm. Before an exploratory laparotomy was performed, acute abdomen with signs of hollow viscus perforation had occurred. An ileum perforation was detected and a right hemicolectomy and ileal resection were performed. The pathological examination showed a classic seminoma of undescended testis. In conclusion, this case is interesting with respect to its clinical picture of acute abdomen due to ileal perforation. The possibility of a germ cell tumor should always be kept in mind in male patients with acute abdomen.
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