Search results

Sort By:

Limit search:

Regulation of immunoglobulin E synthesis

100%

Kuprys I., Kuna P.

Postępy Higieny i Medycyny Doświadczalnej

1997

vol. 51

issue 6

651-682

Immunoglobulin E plays a central role in the pathogenesis of allergic diseases. Therefore an understending of mechanisms which regulate production of IgE is very important. Recent studies have demonstrated that the induction of IgE synthesis in B cells requires two signals. The first one, IgE isotype-specific, is delivered by interleukins 4 or 13 and results in e germ line transcription. The second B-cell-activating factor is responsible for switch recombination and expression of mature eRNA transcripts. This signal is delivered by lymphocytes T, but these cells can be replaced by Epstein-Barr virus infection, protein gp39 (CD40L), monoclonal antibodies to CD40 and CD58, membrane-TNF-a, as well as corticosteroids. Besides this a variety of factors can modulate the IgE synthesis. Interleukin-2, -5, -6, -9, -10, MIPI-a, RANTES and sCD23 enhance the prodution of IgE whereas PAF, PGE2, IL-8, -12 and 18, IFN-a and g, TGF-b, sIL-4R, IL-1Ra, and probably sIL-1R inhibit it. In this article, we review current knowledge about the mechanisms underlying the synthesis of IgE in humans, including molecular events and clinical attempts at redution of the total IgE level in patients with allergic diseases.

Mast cells and cytokines - new insight into the participation of mast cells in inflamatory reactions

100%

Kuprys I., Kuna P.

Postępy Higieny i Medycyny Doświadczalnej

1996

vol. 50

issue 1

43-63

Tissue mast cells are multifunctional immune cells and have been implicated in allergic and inflammatory reactions. They used to be regarded merely as a source of histamin, prostaglandins and leukotriens which mediated the symptoms of the acute allergic reaction but more recent work has indicated they are involved in many inflammatory reactions. The discavory of production and secretion of a unique array of cytokines by these cells has suggested new ways in which they could influence to the development of inflammation. Many experiments have disclosed that mast cells owning to cytokines can not only initiate but also regulate and modulate this process. With the results come the realisation that these cytokines might represent important effector molecules in a variety of pathologic and physiologic processes where mast cells involvment had been postulated but an understanding of the mechanisms remained obscure. The aim of this article is introduction the biology of mast cells and presentation the information concern production and secretion of cytokines by these cells like also influence of these biologically active molecules on inflammatory process.

Refine search results

2 Postępy Higieny i Medycyny Doświadczalnej

1 1997

1 1996

2 Kuna P.

2 Kuprys I.

Search results

Regulation of immunoglobulin E synthesis

Mast cells and cytokines - new insight into the participation of mast cells in inflamatory reactions