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1
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Noradrenaline-induced feeding responses in the rat do not depend on food characteristics

100%
Swiergiel A. H., Wieczorek M.
Acta Neurobiologiae Experimentalis
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2008
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vol. 68
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issue 3
354-361
EN
The noradrenergic system of the hypothalamic paraventricular nuclei (PVN) has been associated with feeding, but whether it controls feeding in a way that is relevant to energy balance is still unclear. Rats were maintained on a high energy, carbohydrate-rich diet (HC), or a low energy, carbohydrate-free, protein-rich diet (LP), until their daily energy intakes equalized. When injected with noradrenaline (NA) into the PVN, they ingested the same amounts of both diets so that the animals on the LP diet consumed only half the total energy of those on the HC diet. Continuous delivery of NA into the PVN via a microdialysis probe induced chewing on non-nutritive pieces of corks. The same chewing pattern could again be elicited by the subsequent NA deliveries. It is concluded that the nutritional value of a diet is irrelevant to the NA feeding response. The failure of NA administration to increase rat feeding in terms of energy intake, combined with its ability to stimulate chewing, suggests that the primary role of the NA system of the PVN may not be controlling the carbohydrate and energy intake, but rather gating behavioral responses that under appropriate circumstances may lead to ingestion.
2
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Bicuculline administration into ventromedial hypothalamus: effects on fear and regional brain monoamines and GABA concentrations in rats

81%
Zagrodzka J., Romaniuk A., Wieczorek M., Boguszewski P.
Acta Neurobiologiae Experimentalis
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2000
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vol. 60
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issue 3
333-343
EN
The effects of bicuculline methiodide administration into ventromedial hypothalamus (15 ng per site, bilaterally) on fear behavior and monoamines (NA, DA, 5-HT) and GABA in structures of the brain defensive system (hypothalamus, midbrain gray matter, amygdala, hippocampus and frontal cortex) were studied. Fear behavior was examined in the modified version of light-dark transition test. The time out from the illuminated compartment of chamber, the time spent there and number of returns to the illuminated compartment was measured. Additionally motor activity, i.e., number of crossings and rearings in dark as well as in the illuminated part of compartment, was registered. Blockade of GABAA receptors in the ventromedial hypothalamus resulted in increased fear behavior, i.e. decrease of time out from illuminated compartment and decrease of the time spent there. Motor behavior remained unchanged. HPLC analysis showed reduction of GABA concentration in all investigated brain structures. An increase of NA concentration in all examined structures with exception of the hypothalamus without effect on MHPG/NA was observed as well. Dopamine level remained unchanged, but DOPAC/DA ratio increased in all structures, except frontal cortex. Also HVA/DA ratio increased in the hypothalamus and midbrain. 5-HT concentration increased only in midbrain, 5-HIAA increased in midbrain and in frontal cortex, and 5-HIAA/5-HT ratio increased only in frontal cortex. These results indicate that GABA-ergic and monoaminergic systems remain in functional interactions and that these interactions may play an important role in the neurochemical regulation of fear behavior. The possible mechanism of GABA - monoaminergic interactions is discussed.
3

A low-level X chromosome mosaicism in mares, detected by chromosome painting

81%
Wieczorek M., Switonski M., Yang F.
Journal of Applied Genetics
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2001
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vol. 42
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issue 2
205-209
EN
Fluorescence in situ hybridization with the use of the equine X whole chromosome painting probe was carried out on chromosome spreads originating from three mares with poor reproductive performance (infertility, miscarriage or stillbirth). The numbers of analysed spreads were high (105, 300 and 480) and in all three mares a low frequency of mosaicism was identified. The mares had the following karyotypes: 64,XX/63,X/65,XXX (93.6%/5.7%/0.7%), 64,XX/63,X (98.9%/1.1%) and 64,XX/63,X (94.3%/5.7%). The incidence and importance of the low percentage X chromosome mosaicism are discussed.
4
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Cost comparison of different configurations of a hybrid energy storage system with battery-only and supercapacitor-only storage in an electric city bus

81%
Wieczorek M., Lewandowski M., Jefimowski W.
Bulletin of the Polish Academy of Sciences: Technical Sciences
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2019
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issue 6
5
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Stationary supercapacitor energy storage operation algorithm based on neural network learning system

72%
Jefimowski W., Nikitenko A., Drążek Z., Wieczorek M., Jefimowski W., Nikitenko A., Drążek Z., Wieczorek M.
Bulletin of the Polish Academy of Sciences: Technical Sciences
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2020
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issue 4
6
Content available remote

Fear behavior and regional brain monoamines distribution after R(+)-8-OHDPAT and R(+)-UH-301 injections into the dorsal raphe nucleus in rats

71%
Koprowska M., Krotewicz M., Romaniuk A., Strzelczuk M., Wieczorek M.
Acta Neurobiologiae Experimentalis
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2002
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vol. 62
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issue 2
63-74
EN
The effects of R(+)-8-Hydroxy-dipropyl-aminotetralin, (R(+)-8-OHDPAT) and R(+)-5-Fluoro-Hydroxy-dipropyloaminotetralin (R(+)-UH-301) injection into the dorsal raphe nucleus (DRN) on fear behavior in a modified version of the light-dark transitions test and regional brain monoamines (NA, DA, 5-HT) and their metabolites ( MHPG, DOPAC, 5-HIAA) in the hypothalamus (HPT), midbrain central gray matter (MID), amygdala (AMY), hippocampus (HIP) and pons (PO) were examined. An injection of R(+)-8-OHDPAT (300 ng) as well R(+)-UH-301 (300 ng) into the DRN evoked i) an increase in the number of head dipping from dark to the illuminated compartment of chamber; ii) an increase of time spent motionless in the dark compartment; iii) decrease of time of locomotion activity in the illuminated compartment. There was no effect on (1) time out from the illuminated to the dark compartment; (2) time of locomotion activity in the dark compartment; (3) time spent motionless in the illuminated compartment; 4) the number of returns from the dark to the illuminated compartment. HPLC analysis showed reduction of 5-HIAA/5-HT ratio in the HPT, HIP and PO, reduction of 5-HT in the MID, increase of NA content in the HPT and AMY, increase of MHPG/NA ratio in the HIP and PO, and increase of DA content in the HPT, AMY and HIP and increase of DOPAC content in the HIP after R(+)-8-OHDPAT injection into the DRN. But injection of R(+)-UH-301 into the DRN reduced 5-HT in the MID and increased in the AMY, reduced 5-HIAA content in the HIP and increased in the MID, reduced NA content in the HIP and increased in the HPT and decreased MHPG/NA ratio in the PO. These results indicate that both 5-HT1A receptor agonists, R(+)-8-OHDPAT and R(+)-UH-301, acting on the 5HT1A autoreceptors caused the anxiolytic effects, reduced fear behavior on the rat connected with infringement of dynamic balance between the serotonergic and catecholaminergics systems.
7
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Behavioral and neurochemical alterations evoked by p-Chlorophenylalanine application in rats examined in the light-dark crossing test

71%
Koprowska M., Krotewicz M., Romaniuk A., Strzelczuk M., Wieczorek M.
Acta Neurobiologiae Experimentalis
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1999
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vol. 59
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issue 1
15-22
EN
The aim of the present study is to examine the effects of serotonin synthesis inhibition with p-Chlorophenylalanine (p-CPA) in rats on (1) anxiety behavior examined in the light-dark crossing test and, (2) regional brain concentration of monoamines (NA, DA and 5-HT) and their metabolites (MHPG, DOPAC, HVA and 5-HIAA) as well as GABA in the hypothalamus, amygdala, hippocampus, midbrain central gray matter and the frontal cortex. Treatment of animals with p-CPA produced a significant increase in time out from the illuminated part of the chamber and in time of locomotor activity in the illuminated part of the chamber. HPLC analysis showed a significant reduction of 5-HT and 5-HIAA concentration in all examined brain regions with the exception of the frontal cortex. Additionally, a significant decrease in DA and its metabolites, DOPAC and HVA occurred in the hypothalamus and amygdala. Moreover, we observed a significant decrease in frontal cortex NA concentration after p-CPA administration. The results of our study suggest that administration of p-CPA is effective in reduction of anxiety through depletion of 5-HT accompanied by diminution of catecholamines, especially DA and its metabolites in the main emotional brain regions.
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