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Review on analgesic effect of co-administrated ibuprofen and caffeine

100%

Polski A., Kasperek R., Sobotka-Polska K., Poleszak E.

Current Issues in Pharmacy and Medical Sciences

2014

vol. 27

issue 1

10-13

Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

A brief analysis of patients suffering from stomach or duodenal ulcers in Almaty hospital №1

88%

Aryzbekova A., Juszkiewicz K. T., Burgess D. E., Polski A., Poleszak E.

Current Issues in Pharmacy and Medical Sciences

2015

vol. 28

issue 4

241-243

Peptic ulcers are a serious problem worldwide, and affect about 4 million people each year. Their etiology is connected with the presence of Helicobacter pylori, the act of smoking, drinking alcohol, being stress, and taking excessively nonsteroidal anti-inflammatory drugs, as well as steroids. The most common symptoms are abdominal pain, nausea, chest pain and fatigue, while less frequent symptoms include vomiting and weight loss. Helicobacter pylori is responsible for about 80% of gastric and 90% of duodenal ulcer cases. In this work, an analysis is made of a correlation between stomach or duodenal ulcer and gender, residence and number of patients hospitalized in the Almaty hospital №1, from 2009-2012, in order to learn about trends in the incidence of these diseases in Kazakhstan. A total number of 950 patients with stomach and duodenal ulcers, in 2009-2012, were questioned. The patient’s residence, gender and stomach or duodenal ulcer problem were taken into account in the study. The result of this work reveals that the largest amount of hospitalized patients suffering from stomach or duodenal ulcers came from urban areas. Moreover, more women than men suffered from peptic ulcers. Furthermore, the number of patients admitted to the hospital due to duodenal ulcers did not show any variation throughout the study. However, the least number of patients suffering from gastric ulcers was noticed in December 2009, and the greatest was in October and November 2011. The obtained data show that ulcers are a serious problem in Kazakhstan.

The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp.

64%

Amangeldykyzy S., Nurlybek A. N., Nurlan A. N., Juszkiewicz K. T., Polski A., Seisembay U. B., Mukasheva A. M., Umirzakovna U. K., Poleszak E.

Current Issues in Pharmacy and Medical Sciences

2015

vol. 28

issue 2

77-80

The ongoing control of virulent bacteria strains is a challenge for today’s medicine. An example of this, is one widely used drug employed in treating less serious external oral and ocular bacterial infections. This is a gel containing both cetalkonium chloride and choline salicylate. However, whether in the era of expanding bacterial resistance this gel is still effective, is not clear. Hence, in our work, its antibacterial effect was studied against 13 strains of Pseudomonas aeruginosa, 6 strains of Staphylococcus spp. and 6 strains of Streptococcus spp. drawn from the collection of the Department of Microbiology, Virology and Immunology, Kazakh National Medical University, as well as against 30 strains of Staphylococcus spp. recently isolated from Kazakh medical students. This work demonstrated that Pseudomonas aeruginosa was insensitive to this preparation in all samples, while the sensitivity of Staphylococcus spp. and Streptococcus spp. was almost halved, compared to untreated samples. An interesting discovery was the greater resistance of strains obtained from student volunteers than from the collection. However, despite the evident resistance of some strains to the combined cetalkonium chloride and choline salicylate gel, we put forward that it can still be used in less serious external bacterial infections.

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3 Current Issues in Pharmacy and Medical Sciences

2 2015

1 2014

3 Poleszak E.

3 Polski A.

2 Juszkiewicz K. T.

1 Amangeldykyzy S.

1 Aryzbekova A.

1 Burgess D. E.

1 Kasperek R.

1 Mukasheva A. M.

1 Nurlan A. N.

1 Nurlybek A. N.

1 Seisembay U. B.

1 Sobotka-Polska K.

1 Umirzakovna U. K.

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Review on analgesic effect of co-administrated ibuprofen and caffeine

A brief analysis of patients suffering from stomach or duodenal ulcers in Almaty hospital №1

The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp.