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1

Biotechnology in Poland

100%
Stec W. J.
Biotechnologia
|
1993
|
issue 4
7-17
EN
The paper presented two definition of biotechnology as well as achivements of new biotechnology.The status of Biotechnology in Poland and the most important topics in biotechnology research was described.
2

Perspectives for medical applications of synthetic oligonucleotides:antisense technology

63%
Stec W. J., Guga P.
Biotechnologia
|
1996
|
issue 4
91-107
EN
Stability of stereoregular oligonucleotides towards selected nucleases, as well as the thermal stability of duplexes formed with DNA and RNa were investigated.Other strategies leading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates with achiral phosphorodithioates or moities like formacetal, sulphones, dietylsiloxanes etc.
3

Oligonucleotides antisense strategy

44%
Stec W. J.
Biotechnologia
|
1994
|
issue 4
5-15
4

Antisense oligonucleotides to PAI-1 mRNA as potential agents for therapeutic intervention in cardiovascular diseases

33%
Cierniewski C. S., Pawlowska Z., Pluskota E., Stasiak M., Kobylanska A., Misiura K., Maciaszek A., Koziolkiewicz M., Stec W. J.
Biotechnologia
|
1996
|
issue 4
141-152
EN
In this report we discuss the possibility of using antisense oligonucleotides specific to PAI-1 mRNA to reversibly decrease PAI-1 level in blood plasma and thus prolong a half-life time endogenous plasminogen activators in circulation.
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