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Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies

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Gondek S., Ogledzinski M., Lin W., Milejczyk K., Juengel B., Potter L., Bachul P. J., Basto L., Perea L., Wang L.-J., Tibudan M., Witkowska Z., Barth R., Fung J., Witkowski P.

European Journal of Translational and Clinical Medicine

2023

vol. 6

issue 1

9-13

Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.

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1 European Journal of Translational and Clinical Medicine

1 2023

1 Bachul P. J.

1 Barth R.

1 Basto L.

1 Fung J.

1 Gondek S.

1 Juengel B.

1 Lin W.

1 Milejczyk K.

1 Ogledzinski M.

1 Perea L.

1 Potter L.

1 Tibudan M.

1 Wang L.-J.

1 Witkowska Z.

1 Witkowski P.

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Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies