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Predicting disease-related genes by topological similarity in human protein-protein interaction network

100%

Zhang L., Hu K., Tang Y.

Open Physics

2010

vol. 8

issue 4

672-682

Predicting genes likely to be involved in human diseases is an important task in bioinformatics field. Nowadays, the accumulation of human protein-protein interactions (PPIs) data provides us an unprecedented opportunity to gain insight into human diseases. In this paper, we adopt the topological similarity in human protein-protein interaction network to predict disease-related genes. As a computational algorithm to speed up the identification of disease-related genes, the topological similarity has substantial advantages over previous topology-based algorithms. First of all, it provides a global measurement of similarity between two vertices. Secondly, quantity which can measure new topological feature has been integrated into the notion of topological similarity. Our method is specially designed for predicting disease-related genes of single disease-gene family. The proposed method is applied to human protein-protein interaction and hepatocellular carcinoma (HCC) data. The results show a significant enrichment of disease-related genes that are characterized by higher topological similarity than other genes.

Catalytic performances of cross-linking humic acids supported Pd/Ni bimetallic catalyst for heck reaction

100%

Xu Q., Zhang L., Shi W., Cui Y.

Polish Journal of Chemical Technology

2009

vol. 11

issue 3

22-26

The cross-linking humic acids (CL-HAs), epichlorohydrin as the cross-linking reagent and the supported Pd/Ni bimetallic catalysts (CL-HAs-Pd/Ni) were prepared and characterized by IR, AAS, XPS, TEM. The effects of reaction time, temperature, base, solvent and the amount of catalyst on the properties of the catalyst were studied. These catalysts could catalyze the Heck reaction of aryl halides and substituted aryl halides with acrylic acids or styrene successfully; the yields were all above 95%.

Preparation and Characterization of Low Temperature Heat-Treated 45S5 Bioactive Glass-Ceramic Analogues

64%

Xie K., Zhang L., Yang X., Wang X., Yang G., Zhang L., Shao H., He Y., Fu J., Gou Z.

vol. 1

issue 1

The 45S5 Bioglassr and its sintered bioactive glass-ceramic (BGC) have been widely investigated as bone implants, mainly for its ability to bond to hard tissues. However, high temperature treatment is not enough to improve its poor mechanical properties, but compromise its biologically relevant performances. The innovative BGC compositions based on the thermally treated 45S5 Bioglassr were developed by decreasing the P2O5 quantity and adding B2O3 (0-6%) into the Na2O–2CaO–3SiO2- based bioactive glasses (BG). The thermally treated BGCs were fully characterized from the microstructural and mechanical points of view and compared to each other. Their bioactivity and bio-dissolutionwere established by means of in vitro soaking tests. The new B2O3-added 45S5 BG analogues, named NCS-xB, can be transformed to crystalline phase (Na2Ca2Si3O9)-based BGCs of high compactness and bioactivity at a relatively low temperature heat treatment (≤ 900ºC), since their bioactivity is preserved. Our experimental results suggest that the new 45S5 BGC analogues with optimized composition exhibit improved micro- structural and mechanical properties, and are beneficial for making specific products such as porous scaffolds or composites for bone defect repair.

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1 Biomedical glasses

1 Open Physics

1 Polish Journal of Chemical Technology

1 2015

1 2010

1 2009

3 Zhang L.

1 Cui Y.

1 Fu J.

1 Gou Z.

1 He Y.

1 Hu K.

1 Shao H.

1 Shi W.

1 Tang Y.

1 Wang X.

1 Xie K.

1 Xu Q.

1 Yang G.

1 Yang X.

Search results

Predicting disease-related genes by topological similarity in human protein-protein interaction network

Catalytic performances of cross-linking humic acids supported Pd/Ni bimetallic catalyst for heck reaction

Preparation and Characterization of Low Temperature Heat-Treated 45S5 Bioactive Glass-Ceramic Analogues