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Down-regulating effect on cellular immunity of the NSF17 factor produced by murine neonatal spleen cells fused with BW 5147 Thymoma cells

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Bubak-Sator M., Machala O., Kubera M., Mazur-Kolecka B., Skowron-Cendrzyk A.
Folia Biologica
|
1992
|
vol. 40
|
issue 1-2
79-82
EN
The non-specific factor NSF17 produced by mouse newborn splenocytes fused with BW 5147 thymona cells was tested in vivo for its immunosuppressive activity. NSF17 administered i.p. in a single dose into adult mice significantly decreased the PHA-induced proliferative response of lymphocytes, regional graft-versus-host reaction, and delayed-type hypersensitivity.
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