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The role of genetic and other biomarkers in NSCLC prognosis

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Schveigert D., Cicenas S., Bublevic J., Askinis R., Sapoka V., Didziapetriene J.
Open Medicine
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2014
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vol. 9
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issue 3
382-390
EN
The development of non-small-cell lung cancer (NSCLC) is a multistep process, which is triggered and maintained by various factors. Many steps of non-small-cell lung carcinogenesis, risk factors and biomarkers have been identified; however no consistent model has been established of personalized medicine for these patients. Distinct various gene expression, products of mutated genes and other markers such as circulating nucleic acids or tumor cells has been proven to be potential biomarkers of non-small cell lung cancer as well as potential targets for new treatment strategies. This article will highlight promising biomarkers in non-small cell lung cancer prognosis.
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Primary malignant peripheral nerve sheath tumour of the heart

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Voluckiene E., Uzdavinys G., Cicenas S., Ivaskeviciene L., Zakarkaite D., Nogiene G.
Open Medicine
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2012
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vol. 7
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issue 5
655-658
EN
A malignant peripheral nerve sheath tumour (MPNST) is a rare variety of soft-tissue sarcoma of ectomesenchymal origin. The World Health Organisation created the term MPNST to replace previous terminology such as malignant schwannoma, malignant neurilemmoma, neurogenic sarcoma, and myxofibrosarcoma for tumours of neurogenic origin with similar biological behavior.[1–3] The vast majority of these tumours develop in extremities. They also tend to be located in unusual sites of the body, such as the pelvic retroperitoneum, infratemporal fossa, intrapericardium, and mediastinum.[1,3,4] This case study presents a patient with an extremely rare primary cardiac MPNST..
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