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1
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The γ-glutamyltransferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups.

100%
Włodek P., Sokołowska M., Smoleński O., Włodek L.
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2002
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vol. 49
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issue 2
501-507
EN
The present work was aimed to obtain information about age-dependent changes of γ-glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl compounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated The results indicate that the activity of GGT and NPSH levels in the kidneys are reduced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the oldest animals. These findings indicate that the capacity for extracellular glutathione degradation and, in consequence, the availability of cysteine for intracellular glutathione biosynthesis may be impaired. The increased PB-Cys level indicates potentiation of the thiolation reaction, i.e. development of protein-mixed disulfides. These results reveal age dependent disturbances in the thiol-disulfide equilibrium in the kidneys which leads to an imbalance between pro- and antioxidatory processes.
2
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2-Methyl-thiazolidine-2,4-dicarboxylic acid protects against paracetamol induced toxicity in human liver derived HepG2 cells

100%
Włodek L., Rommelspacher H.
Acta Biochimica Polonica
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1997
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vol. 44
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issue 4
759-766
3
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Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

88%
Iciek M., Chwatko G., Lorenc-Koci E., Bald E., Włodek L.
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EN
The redox status of plasma thiols can be a diagnostic indicator of different pathological states. The aim of this study was to identify the age dependent changes in the plasma levels of total, free and protein bound glutathione, cysteine and homocysteine. The determination was conducted in plasma of three groups of rats: 1) young (3-month-old), 2) middle aged (19-month-old), and 3) old (31-month-old). Total levels of glutathione, cysteine and homocysteine and their respective free and protein-bound fractions decreased with age. The only exception was a rise in free homocysteine concentration in the middle group, which indicates a different pattern of transformations of this thiol in plasma. The drop in the level of protein-bound thiols suggests that the antioxidant capacity of plasma diminishes with age, which, consequently, leads to impaired protection of -SH groups through irreversible oxidation. The plasma sulfane sulfur level also declines with age, which means that aging is accompanied by inhibition of anaerobic sulfur metabolism.
4
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3-Mercaptopyruvate sulphurtransferase from rat erythrocytes

74%
Włodek L., Ostrowski W. S.
Acta Biochimica Polonica
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1982
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vol. 29
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issue 1-2
121-133
5
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Formation of 2-methyl-2,4-thiazolidinedicarboxylic acid from L-cysteine in rat tissues

74%
Włodek L., Czubak J.
Acta Biochimica Polonica
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1984
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vol. 31
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issue 3
279-288
6
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The reaction of sulfhydryl groups with carbonyl compounds

62%
Włodek L.
Acta Biochimica Polonica
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1988
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vol. 35
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issue 4
307-317
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